1. Anti-infection
  2. Bacterial
  3. LtaS-IN-1

LtaS-IN-1 

Cat. No.: HY-135813
Handling Instructions

LtaS-IN-1 (compound 1771) is a potent small-molecule inhibitor of Lipoteichoic acid (LTA) synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 alone inhibits Enterococcus.spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 combination with antibiotics abolishs multidrug-resistant E. faecium growth almost completely.

For research use only. We do not sell to patients.

LtaS-IN-1 Chemical Structure

LtaS-IN-1 Chemical Structure

CAS No. : 877950-01-1

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Description

LtaS-IN-1 (compound 1771) is a potent small-molecule inhibitor of Lipoteichoic acid (LTA) synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 alone inhibits Enterococcus.spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 combination with antibiotics abolishs multidrug-resistant E. faecium growth almost completely[1].

IC50 & Target

MIC: 0.5 μg/mL (strain E1630); 0.5 μg/mL (strain E1590)[1]

In Vitro

LtaS-IN-1 (0-100 μM) inhibits strain E745 growth as a concentration-dependent manner. At the concentration 10 μM leads to an 60% reduction in the final OD600 for this strain. Meanwhile, LtaS-IN-1 does not affect E. faecium growth in control group[1].
LtaS-IN-1 is against Enterococcus spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 inhibits strain E1630 and E1590 with the MIC values of 0.5μg/mL[1].
LtaS-IN-1 (20 μM) combines with either ampicillin (20 μg/mL), gentamicin (10 μg/mL), linezolid (5 μg/mL), daptomycin (10 μg/mL+50 μg/mL calcium chloride) or vancomycin (20 μg/mL) can inhibit strains E7128 and E7130 growth by 97-100%, while LtaS-IN-1 alone only gives 73% (strain E7128) and 8% (strain E7130) of growth inhibition, respectively[1].

Molecular Weight

427.41

Formula

C₂₄H₁₇N₃O₅

CAS No.

877950-01-1

SMILES

O=C(OCC(NC1=NN=C(C2=CC=CC=C2)O1)=O)CC3=COC4=CC=C5C=CC=CC5=C43

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

LtaS-IN-1BacterialInhibitoranti-bacterialmultidrug-resistantMDRE. faeciuminhibitorinhibit

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