2. Anti-infection
  3. Bacterial Antibiotic
  4. Amphomycin

Amphomycin is a lipopeptide antibiotic that inhibits peptidoglycan synthesis and blocks cell wall development. Amphomycin exhibits potent antibacterial activities against methicillin-resistant S. aureus (MRSA), vancomycin-resistant enterococci (VRE), penicillin-gentamicin-erythromycin-resistant S. pneumonia, and linezolid-quinupristin-dalfopristin-resistant enterococci.

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Amphomycin Chemical Structure

Amphomycin Chemical Structure

CAS No. : 1402-82-0

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Amphomycin Related Antibodies

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Description

Amphomycin is a lipopeptide antibiotic that inhibits peptidoglycan synthesis and blocks cell wall development. Amphomycin exhibits potent antibacterial activities against methicillin-resistant S. aureus (MRSA), vancomycin-resistant enterococci (VRE), penicillin-gentamicin-erythromycin-resistant S. pneumonia, and linezolid-quinupristin-dalfopristin-resistant enterococci[1][2][3].

IC50 & Target

Lipopeptide

 

In Vitro

Amphomycin (40 μ g/mL; 60 min) leads S. aureus to exhibit cell wall thinning and Park’s nucleotide accumulation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Amphomycin Related Antibodies

Cell Viability Assay[1]

Cell Line: S. aureus whole cells
Concentration: 40 μ g/mL
Incubation Time: 60 min
Result: Resulted in the thinning of cell wall and the accumulation of Park’s nucleotide.
In Vivo

Amphomycin (50 mg/kg; p.o.; single) shows low oral availability and (5-10mg/kg; i.v.; single) exhibits a long half-life (5.2-8.0 h in mice and 4.6-7.1 h in rats)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
CAS No.
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References
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Amphomycin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amphomycin1402-82-0BacterialAntibioticS. pneumoniaMRSAVREcell wallbacterialantibiotic resistanceInhibitorinhibitorinhibit

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