1402-82-0
Chemical Structure
Amphomycin
- CAS No.: 1402-82-0
- Formula:C58H91N13O20
- Molecular Weight:1290.42
InChIKey: VNWKTOKETHGBQD-UHFFFAOYSA-N
SMILES: O=C([C@]1([H])CCCN1C([C@@H](NC([C@H](NC(CNC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@]2([H])CCCCN2C3=O)=O)[C@H](C)C(O)=O)=O)CC(O)=O)=O)=O)CC(O)=O)=O)=O)[C@@H](C)N)=O)C(C)C)=O)N[C@@H]([C@@H]3NC([C@H](CC(O)=O)NC(C/C=C\CCCCCC(CC)C)=O)=O)C
Biological Activity: Amphomycin is a lipopeptide antibiotic that inhibits peptidoglycan synthesis and blocks cell wall development. Amphomycin exhibits potent antibacterial activities against methicillin-resistant S. aureus (MRSA), vancomycin-resistant enterococci (VRE), penicillin-gentamicin-erythromycin-resistant S. pneumonia, and linezolid-quinupristin-dalfopristin-resistant enterococci[1][2][3].
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Amphomycin | 96.30% | Amphomycin is a lipopeptide antibiotic that inhibits peptidoglycan synthesis and blocks cell wall development. Amphomycin exhibits potent antibacterial activities against methicillin-resistant S. aureus (MRSA), vancomycin-resistant enterococci (VRE), penicillin-gentamicin-erythromycin-resistant S. pneumonia, and linezolid-quinupristin-dalfopristin-resistant enterococci. | ||||||||||||||||||||
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- [1]. Singh M, et al. Solid-state NMR characterization of amphomycin effects on peptidoglycan and wall teichoic acid biosyntheses in Staphylococcus aureus. Sci Rep. 2016 Aug 19;6:31757. [Content Brief]
- [2]. Pasetka CJ, et al. Novel antimicrobial lipopeptides with long in vivo half-lives. Int J Antimicrob Agents. 2010 Feb;35(2):182-5. [Content Brief]
- [3]. Tanaka H, et al. Amphomycin inhibits phospho-N-acetylmuramyl-pentapeptide translocase in peptidoglycan synthesis of Bacillus. Biochem Biophys Res Commun. 1979 Feb 14;86(3):902-8. [Content Brief]
Keywords
