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Cat. No.: HY-106257AR

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Ceftolozane TFA (Standard)

Ceftolozane TFA (Standard) is the analytical standard of Ceftolozane TFA (HY-106257A). This product is intended for research and analytical applications. Ceftolozane TFA is a cephalosporin antibiotic active against Gram-negative pathogens. Ceftolozane TFA acts as a bactericide and reduces Klebsiella pneumoniae thigh tissue loads in neutropenic mice. Ceftolozane TFA can be used in studies related to bacterial infections.

For research use only. We do not sell to patients.

CAS No.: 1628046-32-1
Formula: C₂₅H₃₁F₃N₁₂O₁₀S₂
Molecular Weight:780.71

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Ceftolozane TFA (Standard) Chemical Structure

CAS No.: 1628046-32-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 1628046-32-1
Molecular Weight 780.71
Formula C₂₅H₃₁F₃N₁₂O₁₀S₂
SMILES

[O-]C(C(F)(F)F)=O.OC(C1=C(C[N+]2=CC(NC(NCCN)=O)=C(N2C)N)CS[C@@]([C@@H]3NC(/C(C4=NSC(N)=N4)=N\OC(C)(C)C(O)=O)=O)([H])N1C3=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gu, J.-Q., et al. (2016, February 25). Salt forms of ceftolozane. World Intellectual Property Organization. WO 2016/028670 A1.

[2]. Martens-Lobenhoffer J, et al. Stability of ceftolozane in human plasma and dried blood spots: Implications for transport and storage. Journal of pharmacological and toxicological methods. 2020;103:106692.

[3]. Yu B, et al. Safety, Tolerability, and Pharmacokinetics of 3 g of Ceftolozane/Tazobactam in Healthy Adults: A Randomized, Placebo-Controlled, Multiple-Dose Study. Clinical pharmacology in drug development. 2018 May;7(4):382-391. [Content Brief]

[4]. Knappe D, et al. Oncocin Onc72 is efficacious against antibiotic-susceptible Klebsiella pneumoniae ATCC 43816 in a murine thigh infection model. Biopolymers. 2015 Nov;104(6):707-11.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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