1628046-32-1
1628046-32-1
Chemical Structure
Ceftolozane TFA
- CAS No.: 1628046-32-1
- Formula:C25H31F3N12O10S2
- Molecular Weight:780.71
InChIKey: PBZOVQQMQQYFDQ-TVNHLQOTSA-N
SMILES: [O-]C(C(F)(F)F)=O.OC(C1=C(C[N+]2=CC(NC(NCCN)=O)=C(N2C)N)CS[C@@]([C@@H]3NC(/C(C4=NSC(N)=N4)=N\OC(C)(C)C(O)=O)=O)([H])N1C3=O)=O
Biological Activity: Ceftolozane TFA is a cephalosporin antibiotic active against Gram-negative pathogens. Ceftolozane TFA acts as a bactericide and reduces Klebsiella pneumoniae thigh tissue loads in neutropenic mice. Ceftolozane TFA can be used in studies related to bacterial infections[1][2][3][4].
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Ceftolozane TFA | 98.17% | Ceftolozane TFA is a cephalosporin antibiotic active against Gram-negative pathogens. Ceftolozane TFA acts as a bactericide and reduces Klebsiella pneumoniae thigh tissue loads in neutropenic mice. Ceftolozane TFA can be used in studies related to bacterial infections. | ||||||||||||||||||||
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Ceftolozane TFA (Standard) | ≥98% | Ceftolozane TFA (Standard) is the analytical standard of Ceftolozane TFA (HY-106257A). This product is intended for research and analytical applications. Ceftolozane TFA is a cephalosporin antibiotic active against Gram-negative pathogens. Ceftolozane TFA acts as a bactericide and reduces Klebsiella pneumoniae thigh tissue loads in neutropenic mice. Ceftolozane TFA can be used in studies related to bacterial infections. | ||||||||||||||||||||
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Ceftolozane-d6 TFA | Ceftolozane-d6 TFA is the deuterated-labeled Ceftolozane TFA (HY-106257A). Ceftolozane TFA is a cephalosporin antibiotic active against Gram-negative pathogens. Ceftolozane TFA acts as a bactericide and reduces Klebsiella pneumoniae thigh tissue loads in neutropenic mice. Ceftolozane TFA can be used in studies related to bacterial infections. | |||||||||||||||||||||
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References
- [1]. Gu, J.-Q., et al. (2016, February 25). Salt forms of ceftolozane. World Intellectual Property Organization. WO 2016/028670 A1.
- [2]. Martens-Lobenhoffer J, et al. Stability of ceftolozane in human plasma and dried blood spots: Implications for transport and storage. Journal of pharmacological and toxicological methods. 2020;103:106692.
- [3]. Yu B, et al. Safety, Tolerability, and Pharmacokinetics of 3 g of Ceftolozane/Tazobactam in Healthy Adults: A Randomized, Placebo-Controlled, Multiple-Dose Study. Clinical pharmacology in drug development. 2018 May;7(4):382-391.
- [4]. Knappe D, et al. Oncocin Onc72 is efficacious against antibiotic-susceptible Klebsiella pneumoniae ATCC 43816 in a murine thigh infection model. Biopolymers. 2015 Nov;104(6):707-11.
