Hydroxymycotrienin A
Hydroxymycotrienin A is an ansamycin group antibiotic with anticancer effects. Hydroxymycotrienin A suppresses integrated HPV18 E6 and E7 gene expression. Hydroxymycotrienin A inhibits growth of HPV-positive cervical cancer cells, stabilizes conformational mutant p53R175H and contact mutant p53R273H via non-covalent interactions, and acts as a non-covalent pharmacological chaperone. Hydroxymycotrienin A can be used for the research of human cervical cancer and non-small cell lung cancer (NSCLC).
For research use only. We do not sell to patients.
- CAS No.: 178550-61-3
- Formula: C36H48N2O9
- Molecular Weight:652.77
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SiHa | IC50 |
0.18 μg/mL
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Antiproliferative activity against human HPV-positive cervical cancer SiHa cells assessed as reduction in cell growth incubated for 3 days by MTT assay.
Antiproliferative activity against human HPV-positive cervical cancer SiHa cells assessed as reduction in cell growth incubated for 3 days by MTT assay.
|
8682718 |
| Ca-Ski | IC50 |
0.15 μg/mL
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Antiproliferative activity against human HPV-positive cervical cancer CaSki cells assessed as reduction in cell growth incubated for 3 days by MTT assay.
Antiproliferative activity against human HPV-positive cervical cancer CaSki cells assessed as reduction in cell growth incubated for 3 days by MTT assay.
|
8682718 |
| HeLa | IC50 |
0.07 μg/mL
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Antiproliferative activity against human HPV-positive cervical cancer HeLa cells assessed as reduction in cell growth incubated for 3 days by MTT assay.
Antiproliferative activity against human HPV-positive cervical cancer HeLa cells assessed as reduction in cell growth incubated for 3 days by MTT assay.
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8682718 |
| C-33-A | IC50 |
0.9 μg/mL
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Antiproliferative activity against human HPV-negative cervical cancer C33A cells assessed as reduction in cell growth incubated for 3 days by MTT assay.
Antiproliferative activity against human HPV-negative cervical cancer C33A cells assessed as reduction in cell growth incubated for 3 days by MTT assay.
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8682718 |
| HT-3 | IC50 |
2.0 μg/mL
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Antiproliferative activity against human HPV-negative cervical cancer HT-3 cells assessed as reduction in cell growth incubated for 3 days by MTT assay.
Antiproliferative activity against human HPV-negative cervical cancer HT-3 cells assessed as reduction in cell growth incubated for 3 days by MTT assay.
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8682718 |
Hydroxymycotrienin A potently inhibits the growth of HPV-positive human cervical cancer cell lines (SiHa, CaSki, HeLa) with IC50 values ranging from 0.07 to 0.18 μg/mL, and is 3-10 times more potent against these lines than against HPV-negative C33A and HT-3 cells[1].
Hydroxymycotrienin A (1 μg/mL; 24 h) inhibits HPV18 E6/E7 gene expression in HeLa cells without significantly altering the expression of a host control gene[1].
Hydroxymycotrienin A (100 μg/mL) shows no antimicrobial activity against tested bacteria, fungi, or yeast[1].
Hydroxymycotrienin A binds human native p53, p53R175H mutant, and p53R273H mutant with high non-covalent affinities (-5.87 kcal/mol, -6.63 kcal/mol, and -6.57 kcal/mol, respectively), outperforming APR-246 in all docking scenarios[2].
Hydroxymycotrienin A (500 ns) acts as a structural stabilizer for human native p53, p53R175H, and p53R273H over 500 ns molecular dynamics simulations, reducing backbone deviations, residue fluctuations, and solvent exposure while preserving structural compactness and maintaining stable hydrogen bond interactions[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 178550-61-3
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Molecular Weight 652.77
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Formula C36H48N2O9
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SMILES
O=C(O[C@@H](C/C=C/C=C/C=C/[C@@H](CC(NC1=C2)=O)OC)[C@@H]([C@@H](O)/C(C)=C\CCC(C1=O)=C(O)C2=O)C)[C@@H](C)NC(C3CCCCC3)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Hosokawa N, et al. Hydroxymycotrienins A and B, new ansamycin group antibiotics. The Journal of antibiotics. 1996 May;49(5):425-31. [Content Brief]
[2]. Rufus AC, et al. Functional restoration of conformational (R175H) and contact (R273H) mutant p53 by -derived Hydroxymycotrienin A in non-small cell lung cancer: a computational approach. Frontiers in bioinformatics. 2026;6:1875897. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hydroxymycotrienin A Related Classifications
HY-N14752 Related Classifications
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