178550-61-3
Chemical Structure
Hydroxymycotrienin A
- CAS No.: 178550-61-3
- Formula:C36H48N2O9
- Molecular Weight:652.77
InChIKey: DRLAPUYORJAEHQ-XBJWRHSSSA-N
SMILES: O=C(O[C@@H](C/C=C/C=C/C=C/[C@@H](CC(NC1=C2)=O)OC)[C@@H]([C@@H](O)/C(C)=C\CCC(C1=O)=C(O)C2=O)C)[C@@H](C)NC(C3CCCCC3)=O
Biological Activity: Hydroxymycotrienin A is an ansamycin group antibiotic with anticancer effects. Hydroxymycotrienin A suppresses integrated HPV18 E6 and E7 gene expression. Hydroxymycotrienin A inhibits growth of HPV-positive cervical cancer cells, stabilizes conformational mutant p53R175H and contact mutant p53R273H via non-covalent interactions, and acts as a non-covalent pharmacological chaperone. Hydroxymycotrienin A can be used for the research of human cervical cancer and non-small cell lung cancer (NSCLC)[1][2].
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Hydroxymycotrienin A | Hydroxymycotrienin A is an ansamycin group antibiotic with anticancer effects. Hydroxymycotrienin A suppresses integrated HPV18 E6 and E7 gene expression. Hydroxymycotrienin A inhibits growth of HPV-positive cervical cancer cells, stabilizes conformational mutant p53R175H and contact mutant p53R273H via non-covalent interactions, and acts as a non-covalent pharmacological chaperone. Hydroxymycotrienin A can be used for the research of human cervical cancer and non-small cell lung cancer (NSCLC). | |||||||||||||||||||||
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- [1]. Hosokawa N, et al. Hydroxymycotrienins A and B, new ansamycin group antibiotics. The Journal of antibiotics. 1996 May;49(5):425-31. [Content Brief]
- [2]. Rufus AC, et al. Functional restoration of conformational (R175H) and contact (R273H) mutant p53 by -derived Hydroxymycotrienin A in non-small cell lung cancer: a computational approach. Frontiers in bioinformatics. 2026;6:1875897. [Content Brief]
Keywords
