1. Anti-infection
  2. Bacterial
  3. JH-LPH-28

JH-LPH-28, a sulfonyl piperazine analog, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. JH-LPH-28 displays outstanding antibiotic activity with a MIC value of 0.83 μg/mL.

For research use only. We do not sell to patients.

JH-LPH-28 Chemical Structure

JH-LPH-28 Chemical Structure

CAS No. : 2414592-36-0

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

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Description

JH-LPH-28, a sulfonyl piperazine analog, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. JH-LPH-28 displays outstanding antibiotic activity with a MIC value of 0.83 μg/mL[1].

In Vitro

JH-LPH-28 displays IC50 values of 0.11 μM against K. pneumoniae LpxH and 0.083 μM against E. coli LpxH, respectively[1].
JH-LPH-28 potently inhibits bacterial growth at 2.8 μg/mL and displayes a MIC value of 1.6 μg/mL against wild-type K. pneumoniae (ATCC 10031)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

471.47

Formula

C21H21F4N3O3S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(N1CCC2=C1C=CC(S(=O)(N3CCN(C4=CC(F)=CC(C(F)(F)F)=C4)CC3)=O)=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (26.51 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1210 mL 10.6051 mL 21.2103 mL
5 mM 0.4242 mL 2.1210 mL 4.2421 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1210 mL 10.6051 mL 21.2103 mL 53.0256 mL
5 mM 0.4242 mL 2.1210 mL 4.2421 mL 10.6051 mL
10 mM 0.2121 mL 1.0605 mL 2.1210 mL 5.3026 mL
15 mM 0.1414 mL 0.7070 mL 1.4140 mL 3.5350 mL
20 mM 0.1061 mL 0.5303 mL 1.0605 mL 2.6513 mL
25 mM 0.0848 mL 0.4242 mL 0.8484 mL 2.1210 mL
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JH-LPH-28 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
JH-LPH-28
Cat. No.:
HY-130837
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