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Cat. No.: HY-182477

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Siccayne

Siccayne, found in the marine basidiomycete Halocyphina villosa and deuteromycete Helminthosporium siccans, is an antibiotic. Siccayne interferes with nucleotide incorporation into DNA and RNA, precursor transport enzymatic reactions, and essential macromolecule synthesis. Siccayne inhibits Gram-positive bacteria and some fungi. Siccayne can be used for research on infections caused by bacteria and fungi.

For research use only. We do not sell to patients.

CAS No.: 22944-03-2
Formula: C₁₁H₁₀O₂
Molecular Weight:174.20

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Please store the product under the recommended conditions in the Certificate of Analysis.

Siccayne Chemical Structure

CAS No.: 22944-03-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

All Antibiotic Isoforms :

In Vitro

Siccayne inhibits the growth of select Gram-positive bacteria (with MIC_s from 10 to 50 μg/mL) and a small subset of fungi (at 50 μg/mL), while most tested bacteria and fungi are resistant at concentrations >50 μg/mL^[1].
Siccayne (2-10 μg/2×10⁶ cells) potently inhibits DNA synthesis (to ~10% of control) at 10 μg/2×10⁶ cells in both normal and Rous-sarcoma-virus-transformed chicken embryo fibroblasts, with weaker inhibition of RNA and protein synthesis^[1].
Siccayne (100 μg/mL) causes slight inhibition of DNA synthesis in toluene-treated Bacillus brevis cells, reducing dTTP incorporation to 62% of control at 100 μg/mL^[1].
Siccayne (100 μg/mL) does not induce hemolysis of bovine erythrocytes at concentrations up to 100 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 22944-03-2
Molecular Weight 174.20
Formula C₁₁H₁₀O₂
SMILES

OC1=CC=C(C(C#CC(C)=C)=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kupka J, et al. Antibiotics from basidiomycetes. XI. The biological activity of siccayne, isolated from the marine fungus Halocyphina villosa J. & E. Kohlmeyer. J Antibiot (Tokyo). 1981 Mar;34(3):298-304. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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Siccayne

All Antibiotic Isoforms