Siccayne 

Siccayne, found in the marine basidiomycete Halocyphina villosa and deuteromycete Helminthosporium siccans, is an antibiotic. Siccayne interferes with nucleotide incorporation into DNA and RNA, precursor transport enzymatic reactions, and essential macromolecule synthesis. Siccayne inhibits Gram-positive bacteria and some fungi. Siccayne can be used for research on infections caused by bacteria and fungi^[1].

Siccayne inhibits the growth of select Gram-positive bacteria (with MIC_s from 10 to 50 μg/mL) and a small subset of fungi (at 50 μg/mL), while most tested bacteria and fungi are resistant at concentrations >50 μg/mL^[1].
Siccayne (2-10 μg/2×10⁶ cells) potently inhibits DNA synthesis (to ~10% of control) at 10 μg/2×10⁶ cells in both normal and Rous-sarcoma-virus-transformed chicken embryo fibroblasts, with weaker inhibition of RNA and protein synthesis^[1].
Siccayne (100 μg/mL) causes slight inhibition of DNA synthesis in toluene-treated Bacillus brevis cells, reducing dTTP incorporation to 62% of control at 100 μg/mL^[1].
Siccayne (100 μg/mL) does not induce hemolysis of bovine erythrocytes at concentrations up to 100 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

174.20

C₁₁H₁₀O₂

22944-03-2

OC1=CC=C(C(C#CC(C)=C)=C1)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kupka J, et al. Antibiotics from basidiomycetes. XI. The biological activity of siccayne, isolated from the marine fungus Halocyphina villosa J. & E. Kohlmeyer. J Antibiot (Tokyo). 1981 Mar;34(3):298-304.