2. Anti-infection
  3. Fungal Bacterial Antibiotic
  4. Nourseothricin sulfate

Nourseothricin sulfate  (Synonyms: Streptothricin sulfate)

Cat. No.: HY-129065 Purity: 93.51%
SDS
COA
Handling Instructions Technical Support

Nourseothricin sulfate (Streptothricin sulfate) is a broad-spectrum antibiotic that destroys the outer membrane of Gram-negative bacteria and is a dominant selective marker for Fonsecaea pedrosoi. Nourseothricin sulfate inhibits protein biosynthesis in prokaryotic cells and strongly inhibits the growth of eukaryotes like fungi and can also be used as a elective marker for a wide range of organisms including bacteria, yeast, filamentous fungi, and plant cells.

For research use only. We do not sell to patients.

Nourseothricin sulfate Chemical Structure

Nourseothricin sulfate Chemical Structure

CAS No. : 96736-11-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

Nourseothricin sulfate Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Nourseothricin sulfate

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Nourseothricin sulfate (Streptothricin sulfate) is a broad-spectrum antibiotic that destroys the outer membrane of Gram-negative bacteria and is a dominant selective marker for Fonsecaea pedrosoi[1][2]. Nourseothricin sulfate inhibits protein biosynthesis in prokaryotic cells and strongly inhibits the growth of eukaryotes like fungi and can also be used as a elective marker for a wide range of organisms including bacteria, yeast, filamentous fungi, and plant cells[3].

In Vitro

Escherichia coli resistance to neurosporin can be sensitive to resistant strains by eliminating their outer membrane resistance. The polycationic antibiotic, Nourseothricin, represents a mixture of several Streptothricins, mainly D and F. Obviously, although very slowly, it can pass the outer membrane via the porin pores. It has been shown earlier that Nourseothricin is able to generate some kind of channels into the outer membrane through which it can pass the cell wall. On the other hand, there are indications that resistant strains containing a Nourseothricin-inactivating acetyl transferase possess an additional protecting system, namely a reduced penetrability of the outer membrane[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nourseothricin sulfate Related Antibodies
In Vivo

Nourseothricin is preferentially excreted via kidney and signs of nephrotoxicity can be observed after its administration. Renal handling of Nourseothricin is characterized in experiments on renal cortical slices under various experimental conditions. Following administration in vivo the renal tubular transport system for organic anions (p-aminohippurate, PAH) is not influenced by Nourseothricin. There is a high degree of accumulation of Nourseothricin in renal cortical slices. In contrast to PAH accumulation there is no influence of nitrogen atmosphere, simultaneous administration of PAH, probenecid or trishydroxyaminomethane on Nourseothricin accumulation. Age dependent differences in Nourseothricin accumulation does not exist[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

1359.47

Formula

C50H94N20O22S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC(O[C@H]1[C@@H](CO)O[C@@H](NC(N2)=N[C@]([C@@]2([H])[C@H](O)CN3)([H])C3=O)[C@H](NC(C[C@@H](N)CCCN(C(C[C@@H](N)CCCNC(C[C@@H](N)CCCN)=O)=O)[H])=O)[C@@H]1O)=O.O=S(O)(O)=O.NC(O[C@H]4[C@@H](CO)O[C@@H](NC(N5)=N[C@]([C@@]5([H])[C@H](O)CN6)([H])C6=O)[C@H](NC(C[C@@H](N)CCCN)=O)[C@@H]4O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (73.56 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7356 mL 3.6779 mL 7.3558 mL
5 mM 0.1471 mL 0.7356 mL 1.4712 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (73.56 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 93.51%

SDS (393 KB)

COA (254 KB) RP-HPLC (294 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.7356 mL 3.6779 mL 7.3558 mL 18.3895 mL
5 mM 0.1471 mL 0.7356 mL 1.4712 mL 3.6779 mL
10 mM 0.0736 mL 0.3678 mL 0.7356 mL 1.8390 mL
15 mM 0.0490 mL 0.2452 mL 0.4904 mL 1.2260 mL
20 mM 0.0368 mL 0.1839 mL 0.3678 mL 0.9195 mL
25 mM 0.0294 mL 0.1471 mL 0.2942 mL 0.7356 mL
30 mM 0.0245 mL 0.1226 mL 0.2452 mL 0.6130 mL
40 mM 0.0184 mL 0.0919 mL 0.1839 mL 0.4597 mL
50 mM 0.0147 mL 0.0736 mL 0.1471 mL 0.3678 mL
60 mM 0.0123 mL 0.0613 mL 0.1226 mL 0.3065 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Nourseothricin sulfate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nourseothricin96736-11-7StreptothricinFungalBacterialAntibioticInhibitorinhibitorinhibit

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