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(Antibiotic C 15003P3; Maytansinol butyrate; C15003P3)
Ansamitocin P-3 Chemical Structure
|Product name: Ansamitocin P-3|
|Cat. No.: HY-15739|
Ansamitocin P-3, a potent anti-tumor maytansinoid found in Actinosynnema pretiosum, is a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29.
IC50 value: 0.015 ng/ml (Antiproliferative activity for primary human endothel cells) 
Target: Microtubule; ADCs cytotoxin
in vitro: Linear calibration curves were obtained in the range 1-500 ng/mL using 0.2 mL rat plasma. The within-day coefficients of variation (CVs) were 12.9, 6.7, and 5.5% and the between-day CVs were 10.4, 6.5, and 6.4% (all n = 5) at 1, 10, and 200 ng/mL, respectively . Ansamitocin P-3 showed potent cytotoxicity against the human solid tumor cell lines A-549, HT-29 .
in vivo: The major pathway of ansamitocin P-3 metabolism in human liver microsomes appears to be demethylation at C-10. The rate of metabolism of ansamitocin P-3 was different in rat and human liver microsomes. About 20% of ansamitocin P-3 was converted to its metabolites in rat liver microsomes and about 70% in human liver microsomes under the same conditions. Additionally, 10-O-demethylated ansamitocin P-3 was also detected in the urine after i.v. bolus administration of ansamitocin P-3 to Sprague-Dawley male rats .
|M.Wt||635.14||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
10 mM in DMSO
|1 mg||5 mg||10 mg|
|1 mM||1.5745 mL||7.8723 mL||15.7446 mL|
|5 mM||0.3149 mL||1.5745 mL||3.1489 mL|
|10 mM||0.1574 mL||0.7872 mL||1.5745 mL|
CAS No.: 66547-09-9 In-stock
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