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Signaling Pathway

Ansamitocin P-3

HY-15739

(Antibiotic C 15003P3; Maytansinol butyrate; C15003P3)

Ansamitocin P-3

Ansamitocin P-3 Chemical Structure

Ansamitocin P-3 is a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29; Antibody drug conjugate cytotoxin.

Size Price Stock Quantity
10 mM * 1 mL in DMSO $182 In-stock
5 mg $130 In-stock
10 mg $190 In-stock
50 mg $450 In-stock
100 mg $600 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL in DMSO €178 In-stock
5 mg €127 In-stock
10 mg €186 In-stock
50 mg €441 In-stock
100 mg €588 In-stock
200 mg Get quote
500 mg Get quote

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Product name: Ansamitocin P-3
Cat. No.: HY-15739

Ansamitocin P-3 Data Sheet

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    Purity: 84.63%

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Biological Activity of Ansamitocin P-3

Ansamitocin P-3, a potent anti-tumor maytansinoid found in Actinosynnema pretiosum, is a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29.
IC50 value: 0.015 ng/ml (Antiproliferative activity for primary human endothel cells) [1]
Target: Microtubule; ADCs cytotoxin
in vitro: Linear calibration curves were obtained in the range 1-500 ng/mL using 0.2 mL rat plasma. The within-day coefficients of variation (CVs) were 12.9, 6.7, and 5.5% and the between-day CVs were 10.4, 6.5, and 6.4% (all n = 5) at 1, 10, and 200 ng/mL, respectively [2]. Ansamitocin P-3 showed potent cytotoxicity against the human solid tumor cell lines A-549, HT-29 [3].
in vivo: The major pathway of ansamitocin P-3 metabolism in human liver microsomes appears to be demethylation at C-10. The rate of metabolism of ansamitocin P-3 was different in rat and human liver microsomes. About 20% of ansamitocin P-3 was converted to its metabolites in rat liver microsomes and about 70% in human liver microsomes under the same conditions. Additionally, 10-O-demethylated ansamitocin P-3 was also detected in the urine after i.v. bolus administration of ansamitocin P-3 to Sprague-Dawley male rats [4].

 

Chemical Information

M.Wt 635.14 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₃₂H₄₃ClN₂O₉
CAS No 66584-72-3
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 1.5745 mL 7.8723 mL 15.7446 mL
5 mM 0.3149 mL 1.5745 mL 3.1489 mL
10 mM 0.1574 mL 0.7872 mL 1.5745 mL

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