1. Protein Tyrosine Kinase/RTK
    Anti-infection
  2. Btk
    Antibiotic
  3. Terreic acid

Terreic acid 

Cat. No.: HY-110013
Handling Instructions

Terreic acid, a quinone epoxide antibiotic, acts as an effective Btk inhibitor. Terreic acid blocks the interaction between PKC and the pleckstrin homology domain of Btk. Terreic acid inhibits the binding of GST-BtkPH to PKC in lysates of HMC-1 human mast cells with an IC50 of approximately 100 μM.

For research use only. We do not sell to patients.

Terreic acid Chemical Structure

Terreic acid Chemical Structure

CAS No. : 121-40-4

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Description

Terreic acid, a quinone epoxide antibiotic, acts as an effective Btk inhibitor. Terreic acid blocks the interaction between PKC and the pleckstrin homology domain of Btk. Terreic acid inhibits the binding of GST-BtkPH to PKC in lysates of HMC-1 human mast cells with an IC50 of approximately 100 μM[1].

IC50 & Target

Btk; Antibiotic[1]

In Vitro

Terreic acid inhibits the association of Btk with PKCβII in mouse mast cells at lower concentrations (IC50 of ≈30 μM). Terreic acid inhibits the catalytic activity of Btk but not PKC[1].
Terreic acid (pretreatment for 30 min before stimulation by antigen for 3 min) inhibits both the basal and activation levels of Btk autophosphorylating activity with IC50s of 10 μM and 3 μM, respectively[1].
Terreic acid inhibits the autophosphorylating activity of Btk purified partially from recombinant baculovirus-infected Sf9 insect cells in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Mouse bone marrow-derived mast cells
Concentration: 0, 5, 10, 20 μM
Incubation Time: Pretreated for 30 min
Result: Inhibited both the basal and activation levels of Btk autophosphorylating activity in a dose-dependent manner.
In Vivo

Terreic acid inhibits the late-phase response of in vivo allergic cutaneous reactions[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice[1]
Dosage: 0, 0.15, 1.5, and 15 mg/kg
Administration: Injected i.p. 1 hr before antigen challenge. Ear thicknesses were measured at 1 hr and 24 hr
Result: The early response, as examined 1 hr after antigen challenge, was not affected by TA.
In contrast, TA inhibited the late-phase (24 hr) response in a dose-dependent manner.
Molecular Weight

154.12

Formula

C₇H₆O₄

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Terreic acid
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HY-110013
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