Terreic acid
Based on 1 publication(s) in Google Scholar
Terreic acid, a quinone epoxide antibiotic, acts as an effective Btk inhibitor. Terreic acid blocks the interaction between PKC and the pleckstrin homology domain of Btk. Terreic acid inhibits the binding of GST-BtkPH to PKC in lysates of HMC-1 human mast cells with an IC50 of approximately 100 μM.
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- CAS. Nr.: 121-40-4
- Formel: C7H6O4
- Molecular Weight:154.12
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Speicherung:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Publications Citing Use of MedChemExpress (MCE) Terreic acid
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Biologische Aktivität
Beschreibung
IC50 & Target
Btk; Antibiotic[1]
In Vitro
Terreic acid inhibits the association of Btk with PKCβII in mouse mast cells at lower concentrations (IC50 of ≈30 μM). Terreic acid inhibits the catalytic activity of Btk but not PKC[1].
Terreic acid (pretreatment for 30 min before stimulation by antigen for 3 min) inhibits both the basal and activation levels of Btk autophosphorylating activity with IC50s of 10 μM and 3 μM, respectively[1].
Terreic acid inhibits the autophosphorylating activity of Btk purified partially from recombinant baculovirus-infected Sf9 insect cells in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:Mouse bone marrow-derived mast cells
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Concentration:0, 5, 10, 20 μM
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Incubation Time:Pretreated for 30 min
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Result:Inhibited both the basal and activation levels of Btk autophosphorylating activity in a dose-dependent manner.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c mice[1]
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Dosage:0, 0.15, 1.5, and 15 mg/kg
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Administration:Injected i.p. 1 hr before antigen challenge. Ear thicknesses were measured at 1 hr and 24 hr
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Result:The early response, as examined 1 hr after antigen challenge, was not affected by TA.
In contrast, TA inhibited the late-phase (24 hr) response in a dose-dependent manner.
Chemical Information
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CAS. Nr. 121-40-4
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Appearance Solid
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Molecular Weight 154.12
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Formel C7H6O4
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Color White to off-white
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SMILES
O=C1[C@@H]2[C@H](C(C(O)=C1C)=O)O2
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Structure Classification
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Initial Source
Aspergillus terreus Thorn. var terreus
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Reinheit & Dokumentation
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Data Sheet (288 KB)
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SDS (392 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Terreic acid Related Classifications
HY-110013 Related Classifications
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