Terreic acid
Based on 1 publication(s) in Google Scholar
Terreic acid, a quinone epoxide antibiotic, acts as an effective Btk inhibitor. Terreic acid blocks the interaction between PKC and the pleckstrin homology domain of Btk. Terreic acid inhibits the binding of GST-BtkPH to PKC in lysates of HMC-1 human mast cells with an IC50 of approximately 100 μM.
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- CAS No.: 121-40-4
- Formule: C7H6O4
- Masse moléculaire:154.12
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Stockage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Activité biologique
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Activité biologique
Btk; Antibiotic[1]
Terreic acid inhibits the association of Btk with PKCβII in mouse mast cells at lower concentrations (IC50 of ≈30 μM). Terreic acid inhibits the catalytic activity of Btk but not PKC[1].
Terreic acid (pretreatment for 30 min before stimulation by antigen for 3 min) inhibits both the basal and activation levels of Btk autophosphorylating activity with IC50s of 10 μM and 3 μM, respectively[1].
Terreic acid inhibits the autophosphorylating activity of Btk purified partially from recombinant baculovirus-infected Sf9 insect cells in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Mouse bone marrow-derived mast cells
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Concentration:0, 5, 10, 20 μM
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Incubation Time:Pretreated for 30 min
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Result:Inhibited both the basal and activation levels of Btk autophosphorylating activity in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c mice[1]
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Dosage:0, 0.15, 1.5, and 15 mg/kg
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Administration:Injected i.p. 1 hr before antigen challenge. Ear thicknesses were measured at 1 hr and 24 hr
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Result:The early response, as examined 1 hr after antigen challenge, was not affected by TA.
In contrast, TA inhibited the late-phase (24 hr) response in a dose-dependent manner.
Chemical Information
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CAS No. 121-40-4
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Appearance Solid
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Masse moléculaire 154.12
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Formule C7H6O4
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Color White to off-white
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SMILES
O=C1[C@@H]2[C@H](C(C(O)=C1C)=O)O2
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
Pureté et documentation
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Fiche technique (275 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Terreic acid Related Classifications
HY-110013 Related Classifications
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