121-40-4
121-40-4
Chemical Structure
Terreic acid
- CAS No.: 121-40-4
- Formula:C7H6O4
- Molecular Weight:154.12
IUPAC Name: (1R,6S)-3-hydroxy-4-methyl-7-oxabicyclo[4.1.0]hept-3-ene-2,5-dione
InChIKey: ATFNSNUJZOYXFC-RQJHMYQMSA-N
SMILES: O=C1[C@@H]2[C@H](C(C(O)=C1C)=O)O2
Biological Activity: Terreic acid, a quinone epoxide antibiotic, acts as an effective Btk inhibitor. Terreic acid blocks the interaction between PKC and the pleckstrin homology domain of Btk. Terreic acid inhibits the binding of GST-BtkPH to PKC in lysates of HMC-1 human mast cells with an IC50 of approximately 100 μM[1].
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Terreic acid | Terreic acid, a quinone epoxide antibiotic, acts as an effective Btk inhibitor. Terreic acid blocks the interaction between PKC and the pleckstrin homology domain of Btk. Terreic acid inhibits the binding of GST-BtkPH to PKC in lysates of HMC-1 human mast cells with an IC50 of approximately 100 μM. | |||||||||||||||||||||
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References
Keywords
