1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Capreomycin

Capreomycin 

Cat. No.: HY-P3270
Handling Instructions

Capreomycin is a macrocyclic peptide antibiotic. Capreomycin can be used for anti-multidrug-resistant-tuberculosis research. Capreomycin can inhibit phenylalanine synthesis in in mycobacterial ribosomes translation

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Capreomycin Chemical Structure

Capreomycin Chemical Structure

CAS No. : 11003-38-6

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Description

Capreomycin is a macrocyclic peptide antibiotic. Capreomycin can be used for anti-multidrug-resistant-tuberculosis research. Capreomycin can inhibit phenylalanine synthesis in in mycobacterial ribosomes translation[1][2]

IC50 & Target

Aminoglycoside

 

In Vivo

Capreomycin (1.4, 7.2, and 14.5 mg/kg for inhale; 20 mg/kg for i.m.; 4 weeks) decreases the wet lung weight and lowers bacterial burden in the lungs of infected guinea pigs[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male guinea pigs [836 ± 162.3 g; infected via the respiratory route with nebulized suspensions 2 × 105 CFU/mL of Mycobacterium tuberculosis (strain H37Rv)][2]
Dosage: 1.4, 7.2, and 14.5 mg/kg for inhale; 20 mg/kg for i.m.
Administration: Inhaling or i.m.; 4 weeks
Result: Significantly decreased the wet lung weight at 14.5 mg/kg, and smaller than receiving 1.4 mg/kg group and controls.
Significantly lowered bacterial burden in the lungs (3.52 ± 0.20 CFU/mL; P < 0.05) at 14.5 mg/kg than controls (4.58 ± 0.20 CFU/mL) and at 1.4 and 7.2 mg/kg (4.02 ± 0.32 and 4.01 ± 0.29 CFU/mL, respectively).
Clinical Trial
CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Capreomycin
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HY-P3270
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