Sarubicin B
Sarubicin B is an active product that can be isolated from the culture filtrate of a Streptomyces strain JA 2861. Sarubicin B is a quinone antibiotic that inhibit Gram-positive bacteria and not active against Gram-negative microorganisms.
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- CAS No.: 84745-01-7
- Formule: C13H10N2O4
- Masse moléculaire:258.23
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 4T1 | IC50 |
7.6 μM
Compound: 2
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Cytotoxicity against mouse 4T1 cells assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay
Cytotoxicity against mouse 4T1 cells assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay
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[PMID: 35213166] |
| A549 | IC50 |
13.5 μM
Compound: 2
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Cytotoxicity against human A549 cells assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay
Cytotoxicity against human A549 cells assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay
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[PMID: 35213166] |
| HCT-116 | IC50 |
14.8 μM
Compound: 2
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Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay
Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay
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[PMID: 35213166] |
| HepG2 | IC50 |
6.3 μM
Compound: 2
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Cytotoxicity against human HepG2 cells assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay
Cytotoxicity against human HepG2 cells assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay
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[PMID: 35213166] |
Chemical Information
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CAS No. 84745-01-7
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Masse moléculaire 258.23
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Formule C13H10N2O4
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SMILES
O=C(N)C(C1=O)=C(C(C2=C1C=CC=C2C(C)=O)=O)N
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Structure Classification
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Initial Source
streptomyces strain
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Gram Staining of Tissue Sections
Gram staining of tissue sections is a histochemical technique used to differentiate Gram-positive and Gram-negative bacteria within histological specimens based on differences in bacterial cell wall structure and dye retention, adapted from classical bacteriological Gram staining into tissue-compatible “histological Gram stain” variants. In tissue applications, modifications of the Brown-Hopps and Brown-Brenn methods are commonly used to improve differentiation of microorganisms embedded within host connective tissue and to reduce overstaining or loss of Gram-negative signal, which are known limitations of earlier approaches. The principle relies on crystal violet-iodine complex retention in Gram-positive organisms and subsequent decolorization and counterstaining steps that allow contrast visualization of Gram-negative organisms against tissue background.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sarubicin B Related Classifications
HY-123436 Related Classifications
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