1. Anti-infection
  2. Bacterial
  3. JH-LPH-33

JH-LPH-33 

Cat. No.: HY-130838
Handling Instructions

JH-LPH-33, a sulfonyl piperazine analog, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. JH-LPH-33 displays outstanding antibiotic activity with a MIC value of 0.66 μg/mL.

For research use only. We do not sell to patients.

JH-LPH-33 Chemical Structure

JH-LPH-33 Chemical Structure

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Description

JH-LPH-33, a sulfonyl piperazine analog, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. JH-LPH-33 displays outstanding antibiotic activity with a MIC value of 0.66 μg/mL[1].

In Vitro

JH-LPH-33 displays IC50 values of 0.026 μM against K. pneumoniae LpxH and 0.046 μM against E. coli LpxH, respectively[1].
JH-LPH-33 potently inhibits bacterial growth at 1.6 μg/mL and displayes a MIC value of >64 μg/mL against E. coli[1].

Molecular Weight

487.92

Formula

C₂₁H₂₁ClF₃N₃O₃S

SMILES

CC(N1CCC2=C1C=CC(S(=O)(N3CCN(C4=CC(Cl)=CC(C(F)(F)F)=C4)CC3)=O)=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

JH-LPH-33BacterialSulfonylpiperazineanalogUDP-2,3-diacylglucosaminepyrophosphatehydrolaseLpxHantibioticInhibitorinhibitorinhibit

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