2. Metabolic Enzyme/Protease Anti-infection
  3. Enolase Bacterial Antibiotic
  4. SF2312

SF2312, a natural phosphonate antibiotic (Antibiotic), is a highly potent Enolase inhibitor with IC50s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively. SF2312 is active against bacteria under anaerobic conditions.

For research use only. We do not sell to patients.

SF2312 Chemical Structure

SF2312 Chemical Structure

CAS No. : 107729-45-3

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Based on 1 publication(s) in Google Scholar

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SF2312 Related Antibodies

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Description

SF2312, a natural phosphonate antibiotic (Antibiotic), is a highly potent Enolase inhibitor with IC50s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively. SF2312 is active against bacteria under anaerobic conditions[1].

In Vitro

SF2312 is selectively toxic to ENO1-deleted glioma cells. SF2312 inhibits the proliferation (2 weeks treatment course) of the ENO1-deleted D423 glioma cell line in the low μM range whist isogenically ENO1-rescued D423 cells, ectopically re-expressing ENO1 only shows inhibition of proliferation at concentrations of SF2312 above 200 μM. SF2312 (10 μM) dose-dependently reduces the conversion of U-13C glucose to 13C lactate in a manner selective for ENO1-deleted over ENO1-rescued or otherwise ENO1-intact glioma cells[1].
SF2312 is produced by the actinomycete Micromonospora and is active against a range of bacteria, with strong activity against Salmonella and Staphylococcus, weak activity against E. coli, and no activity against fungi[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SF2312 Related Antibodies
Molecular Weight

197.08

Formula

C4H8NO6P
CAS No.
Appearance

Oil

Color

Light yellow to yellow

SMILES

O=C1N(C(CC1P(O)(O)=O)O)O
Structure Classification
Initial Source

Micromonospora sp
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (634.26 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0741 mL 25.3704 mL 50.7408 mL
5 mM 1.0148 mL 5.0741 mL 10.1482 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.0741 mL 25.3704 mL 50.7408 mL 126.8520 mL
5 mM 1.0148 mL 5.0741 mL 10.1482 mL 25.3704 mL
10 mM 0.5074 mL 2.5370 mL 5.0741 mL 12.6852 mL
15 mM 0.3383 mL 1.6914 mL 3.3827 mL 8.4568 mL
20 mM 0.2537 mL 1.2685 mL 2.5370 mL 6.3426 mL
25 mM 0.2030 mL 1.0148 mL 2.0296 mL 5.0741 mL
30 mM 0.1691 mL 0.8457 mL 1.6914 mL 4.2284 mL
40 mM 0.1269 mL 0.6343 mL 1.2685 mL 3.1713 mL
50 mM 0.1015 mL 0.5074 mL 1.0148 mL 2.5370 mL
60 mM 0.0846 mL 0.4228 mL 0.8457 mL 2.1142 mL
80 mM 0.0634 mL 0.3171 mL 0.6343 mL 1.5857 mL
100 mM 0.0507 mL 0.2537 mL 0.5074 mL 1.2685 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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SF2312 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SF2312107729-45-3SF 2312SF-2312EnolaseBacterialAntibioticPhosphopyruvate hydratasephosphonate antibioticENO1ENO2bacteriaanaerobic conditionsInhibitorinhibitorinhibit

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