107729-45-3
Chemical Structure
SF2312
- CAS No.: 107729-45-3
- Formula:C4H8NO6P
- Molecular Weight:197.08
IUPAC Name: (1,5-dihydroxy-2-oxopyrrolidin-3-yl)phosphonic acid
InChIKey: CGWBGDOPBYWJKZ-UHFFFAOYSA-N
SMILES: O=C1N(C(CC1P(O)(O)=O)O)O
Biological Activity: SF2312 is a phosphonate Antibiotic and Enolase inhibitor, with an IC50 of 18.4 nM against E. coli enolase. SF2312 reduces intracellular ATP levels and inhibits glycolytic flux. SF2312 exhibits activity against both Gram-positive and Gram-negative bacteria, and exerts synergistic effects against E. coli when combined with Fosfomycin (HY-B1075A). SF2312 shows selective toxicity toward gliomas with ENO1 gene knockout. SF2312 can be used in research related to bacterial infections and gliomas[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SF2312 | 95.0% | SF2312 is a phosphonate Antibiotic and Enolase inhibitor, with an IC50 of 18.4 nM against E. coli enolase. SF2312 reduces intracellular ATP levels and inhibits glycolytic flux. SF2312 exhibits activity against both Gram-positive and Gram-negative bacteria, and exerts synergistic effects against E. coli when combined with Fosfomycin (HY-B1075A). SF2312 shows selective toxicity toward gliomas with ENO1 gene knockout. SF2312 can be used in research related to bacterial infections and gliomas. | ||||||||||||||||||||
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References
- [1]. Krucinska J, et al. Functional and structural basis of E. coli enolase inhibition by SF2312: a mimic of the carbanion intermediate. Sci Rep. 2019;9(1):17106. Published 2019 Nov 19. [Content Brief]
- [2]. Milanes JE, et al. Enolase inhibitors as therapeutic leads for Naegleria fowleri infection. PLoS Pathog. 2024;20(8):e1012412. Published 2024 Aug 1. [Content Brief]
- [3]. Leonard PG, et al. SF2312 is a natural phosphonate inhibitor of enolase. Nat Chem Biol. 2016;12(12):1053-1058. [Content Brief]
