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  3. D13-9001

D13-9001 

Cat. No.: HY-124819
Handling Instructions

D13-9001 is a potent AcrB (AcrAB-TolC efflux pump subunit) and MexB (MexAB-OprM efflux pump subunit) inhibitor with the KD values of 1.15 μM and 3.57 μM in E. coli and P. aeruginosa, respectively. D13-9001 exhibits antibiotic activities.

For research use only. We do not sell to patients.

D13-9001 Chemical Structure

D13-9001 Chemical Structure

CAS No. : 957471-96-4

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Description

D13-9001 is a potent AcrB (AcrAB-TolC efflux pump subunit) and MexB (MexAB-OprM efflux pump subunit) inhibitor with the KD values of 1.15 μM and 3.57 μM in E. coli and P. aeruginosa, respectively[1]. D13-9001 exhibits antibiotic activities[2].

IC50 & Target

KD: 1.15 μM (AcrB), 3.57 μM (MexB)[1]

In Vitro

D13-9001 exhibits high solubility and a good safety profile[3].

In Vivo

D13-9001 (1.25-20 mg/kg; intravenous drip infusion; 2 hours) with aztreonam (AZT) gives improved survival rates in a lethal pneumonia rats at the end of day seven compared with AZT treated alone[3].

Animal Model: SD rats (Pulmonary infection by P. aeruginosa PAM1020)[3]
Dosage: 1.25 mg/kg, 5 mg/kg, 20 mg/kg
Administration: Intravenous drip infusion; 2 hours
Result: The combination of 1.25, 5, and 20 mg/kg of D13-9001 with 1000 mg/kg of AZT gave improved survival rates at the end of day seven, whereas no obvious effect was observed on treatment with AZT alone.
Molecular Weight

693.78

Formula

C₃₁H₃₉N₁₁O₆S

CAS No.

957471-96-4

SMILES

O=C(NCC[N+](C)(CC([O-])=O)C)O[[email protected]]1CN(C(N=C2N3C=CC(C(NC4=NC(C(C)(C)C)=CS4)=O)=C2)=C(/C=C/C5=NN=NN5)C3=O)CCC1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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D13-9001
Cat. No.:
HY-124819
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