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  3. D13-9001

D13-9001 

Cat. No.: HY-124819
Handling Instructions

D13-9001 is a potent AcrB (AcrAB-TolC efflux pump subunit) and MexB (MexAB-OprM efflux pump subunit) inhibitor with the KD values of 1.15 μM and 3.57 μM in E. coli and P. aeruginosa, respectively. D13-9001 exhibits antibiotic activities.

For research use only. We do not sell to patients.

D13-9001 Chemical Structure

D13-9001 Chemical Structure

CAS No. : 957471-96-4

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Description

D13-9001 is a potent AcrB (AcrAB-TolC efflux pump subunit) and MexB (MexAB-OprM efflux pump subunit) inhibitor with the KD values of 1.15 μM and 3.57 μM in E. coli and P. aeruginosa, respectively[1]. D13-9001 exhibits antibiotic activities[2].

IC50 & Target

KD: 1.15 μM (AcrB), 3.57 μM (MexB)[1]

In Vitro

D13-9001 exhibits high solubility and a good safety profile[3].

In Vivo

D13-9001 (1.25-20 mg/kg; intravenous drip infusion; 2 hours) with aztreonam (AZT) gives improved survival rates in a lethal pneumonia rats at the end of day seven compared with AZT treated alone[3].

Animal Model: SD rats (Pulmonary infection by P. aeruginosa PAM1020)[3]
Dosage: 1.25 mg/kg, 5 mg/kg, 20 mg/kg
Administration: Intravenous drip infusion; 2 hours
Result: The combination of 1.25, 5, and 20 mg/kg of D13-9001 with 1000 mg/kg of AZT gave improved survival rates at the end of day seven, whereas no obvious effect was observed on treatment with AZT alone.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

693.78

Formula

C₃₁H₃₉N₁₁O₆S

CAS No.

957471-96-4

SMILES

O=C(NCC[N+](C)(CC([O-])=O)C)O[[email protected]]1CN(C(N=C2N3C=CC(C(NC4=NC(C(C)(C)C)=CS4)=O)=C2)=C(/C=C/C5=NN=NN5)C3=O)CCC1

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
D13-9001
Cat. No.:
HY-124819
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D13-9001

Cat. No.: HY-124819