2. Cell Cycle/DNA Damage Anti-infection
  3. DNA/RNA Synthesis Bacterial Antibiotic
  4. Nogalamycin

Nogalamycin is an anthracyclinone antibiotic. Nogalamycin is a potent antibiotic against Gram-positive bacteria, also has cytotoxicity against certain tumor cells. Nogalamycin is produced by Streptomyces nogalater var. Nogalater. Nogalamycin selectively inhibits RNA synthesis after binding to DNA template. Nogalamycin can be used for researching anticancer.

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Nogalamycin Chemical Structure

Nogalamycin Chemical Structure

CAS No. : 1404-15-5

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Nogalamycin Related Antibodies

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Description

Nogalamycin is an anthracyclinone antibiotic. Nogalamycin is a potent antibiotic against Gram-positive bacteria, also has cytotoxicity against certain tumor cells. Nogalamycin is produced by Streptomyces nogalater var. Nogalater. Nogalamycin selectively inhibits RNA synthesis after binding to DNA template. Nogalamycin can be used for researching anticancer[1][2].

IC50 & Target

RNA Synthesis[2]
In Vitro

Nogalamycin (0-10 μg/ml; 2 hours) exhibits lethality against CHO, L1210 and B16 with LD50s of 2.74 μg/ml, 0.25 μg/ml and 0.15 μg/ml[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nogalamycin Related Antibodies

Cell Cytotoxicity Assay

Cell Line: CHO, L1210 and B16 cells[1]
Concentration: 0-10 μg/ml
Incubation Time: 2 hours
Result: Exhibited lethality against CHO, L1210 and B16 with LD50s of 2.74 μg/ml, 0.25 μg/ml and 0.15 μg/ml.
In Vivo

Nogalamycin (0-1000 mug/kg; IP) can regress chemically-induced fibrosarcoma tumors and tumors of spontaneous origin in rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[1]
Dosage: 0-1000 mug/kg
Administration: IP
Result: Regressed chemically-induced fibrosarcoma tumors and tumors of spontaneous origin in rats, and the most effective concentration was 556 mug/kg.
Molecular Weight

787.80

Formula

C39H49NO16
CAS No.
Appearance

Solid

Color

Orange to red

SMILES

O=C1C2=C(C(C3=C1C=C4C([C@H](C[C@](C)(O)[C@@H]4C(OC)=O)O[C@@]5([H])[C@@H]([C@@](C)([C@@H](OC)[C@H](C)O5)OC)OC)=C3O)=O)C(O)=CC6=C2O[C@]([C@@H](O)[C@H](N(C)C)[C@H]7O)([H])O[C@]67C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (12.69 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2694 mL 6.3468 mL 12.6936 mL
5 mM 0.2539 mL 1.2694 mL 2.5387 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥97.0%

COA (258 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2694 mL 6.3468 mL 12.6936 mL 31.7339 mL
5 mM 0.2539 mL 1.2694 mL 2.5387 mL 6.3468 mL
10 mM 0.1269 mL 0.6347 mL 1.2694 mL 3.1734 mL
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Nogalamycin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nogalamycin1404-15-5DNA/RNA SynthesisBacterialAntibioticAnticancerAntitumorCHOL1210B16CytotoxicityGram-positive bacteriaInhibitorinhibitorinhibit

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