1404-15-5
Chemical Structure
Nogalamycin
- CAS No.: 1404-15-5
- Formula:C39H49NO16
- Molecular Weight:787.80
IUPAC Name: methyl (2R,3S,4R,5R,6R,11S,13S,14R)-4-(dimethylamino)-3,5,8,10,13-pentahydroxy-6,13-dimethyl-9,16-dioxo-11-(((2R,3R,4R,5S,6S)-3,4,5-trimethoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-3,4,5,6,9,11,12,13,14,16-decahydro-2H-2,6-epoxytetraceno[1,2-b]oxocine-14-carboxylate
InChIKey: KGTDRFCXGRULNK-JYOBTZKQSA-N
SMILES: O=C1C2=C(C(C3=C1C=C4C([C@H](C[C@](C)(O)[C@@H]4C(OC)=O)O[C@@]5([H])[C@@H]([C@@](C)([C@@H](OC)[C@H](C)O5)OC)OC)=C3O)=O)C(O)=CC6=C2O[C@]([C@@H](O)[C@H](N(C)C)[C@H]7O)([H])O[C@]67C
Biological Activity: Nogalamycin is an anthracyclinone antibiotic. Nogalamycin is a potent antibiotic against Gram-positive bacteria, also has cytotoxicity against certain tumor cells. Nogalamycin is produced by Streptomyces nogalater var. Nogalater. Nogalamycin selectively inhibits RNA synthesis after binding to DNA template. Nogalamycin can be used for researching anticancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Nogalamycin | 97.2% | Nogalamycin is an anthracyclinone antibiotic. Nogalamycin is a potent antibiotic against Gram-positive bacteria, also has cytotoxicity against certain tumor cells. Nogalamycin is produced by Streptomyces nogalater var. Nogalater. Nogalamycin selectively inhibits RNA synthesis after binding to DNA template. Nogalamycin can be used for researching anticancer. | ||||||||||||||||||||
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- [1]. Bhuyan BK, et al. Cell kill kinetics of several nogalamycin analogs and adriamycin for Chinese hamster ovary, L1210 leukemia, and B16 melanoma cells in culture. Cancer Res. 1981;41(1):18-24. [Content Brief]
- [2]. Bhuyan BK, et al. Differential interaction of nogalamycin with DNA of varying base composition. Proc Natl Acad Sci U S A. 1965;54(2):566-572. [Content Brief]
Keywords
