Rudolfomycin
Rudolfomycin is an anthracycline Antibiotic, composed of the aglycone ε-pyrromycinone and three glycosyl sugar units. Rudolfomycin inhibits the growth of mammalian tumors and exhibits antibacterial activity against Gram-positive bacteria. Rudolfomycin can be used in the research of leukemia and Gram-positive bacterial infections.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 69245-38-1
- 화학식: C42H52N2O16
- 분자량:840.87
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
All Antibiotic Isoforms
More
Biological Activity
Rudolfomycin (0.25-8 μg/mL) potently inhibits the growth of gram-positive bacteria including Streptococcus pneumoniae A-9585 (MIC 0.25 μg/mL), Streptococcus pyogenes A-9604 (MIC 0.5 μg/mL), Staphylococcus aureus A-9537 (MIC 2 μg/mL), Staphylococcus aureus A-9606 (MIC 8 μg/mL), and Streptococcus faecalis A-20688 (MIC 4 μg/mL), but is inactive against gram-negative bacteria and most tested fungi[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:BDF1 mice (female; implanted i.p. with 106 L-1210 leukemia ascites cells)[1]
-
Dosage:12.8, 6.4, 3.2, 1.6, 0.8, 0.4 mg/kg
6.4, 3.2, 1.6, 0.8, 0.4, 0.2 mg/kg
3.2, 1.6, 0.8, 0.4, 0.2, 0.1 mg/kg
1.6, 0.8, 0.4, 0.2, 0.1, 0.05 mg/kg -
Administration:i.p.; single dose
i.p.; days 1, 4, 7
i.p.; daily, 5 days
i.p.; daily, 9 days -
Result:Attained the peak median survival time (MST) of 10.0 days and maximal % T/C value of 143 across single intraperitoneal (i.p.) bolus, intermittent day 1/4/7 i.p., 5-day daily i.p. and 9-day daily i.p. schedules at corresponding medium dose groups.
Attained a secondary MST of 9.5 days with a % T/C of 136 only in the day 1/4/7 intermittent i.p. group treated with 0.8 mg/kg.
Attained a consistent MST of 9.0 days and % T/C of 129 at multiple dosages covering all four administration modes.
Attained a uniform MST of 8.0 days and % T/C of 114 across low-dose cohorts of all four dosing regimens.
Attained a moderate MST of 7.5 days with a % T/C of 107 in the 9-day daily i.p. group at 1.6 and 0.1 mg/kg.
Attained the lowest MST of 7.0 days with a % T/C of 100 under day 1/4/7 intermittent i.p. administration at 3.2 mg/kg.
Chemical Information
-
CAS No. 69245-38-1
-
분자량 840.87
-
화학식 C42H52N2O16
-
SMILES
O=C(C1[C@@](O)(CC)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4C(N)=CC([C@@H](C)O4)=O)[C@H](C)O3)[C@H](C)O2)C5=C(O)C6=C(C(C7=C(O)C=CC(O)=C7C6=O)=O)C=C15)OC
-
Structure Classification
-
Initial Source
Actinosporangium species ATCC 31127
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Rudolfomycin Related Classifications
HY-126731 Related Classifications
Powered by Bioz