1. Anti-infection
  2. Antibiotic
    Bacterial
  3. Tulathromycin A

Tulathromycin A (Synonyms: Tulathromycin; CP 472295)

Cat. No.: HY-15662 Purity: >98.0%
Handling Instructions

Tulathromycin A (Tulathromycin), a macrolide antibiotic, inhibits protein synthesis (IC50=0.26 µM) by targeting bacterial ribosome. Tulathromycin A is used for the research of respiratory disease in cattle and swine. Immunomodulatory effects.

For research use only. We do not sell to patients.

Tulathromycin A Chemical Structure

Tulathromycin A Chemical Structure

CAS No. : 217500-96-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 64 In-stock
Estimated Time of Arrival: December 31
10 mg USD 72 In-stock
Estimated Time of Arrival: December 31
25 mg USD 155 In-stock
Estimated Time of Arrival: December 31
50 mg USD 285 In-stock
Estimated Time of Arrival: December 31
100 mg USD 437 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Tulathromycin A (Tulathromycin), a macrolide antibiotic, inhibits protein synthesis (IC50=0.26 µM) by targeting bacterial ribosome. Tulathromycin A is used for the research of respiratory disease in cattle and swine. Immunomodulatory effects[1][2][3].

In Vitro

Tulathromycin A (Tulathromycin) represents the first member of a novel subclass of macrolides, known as triamilides[1].
Tulathromycin A (0.02 to 2.0 mg/mL) induces time- and concentration-dependent apoptosis in neutrophils, which enhances their subsequent clearance by macrophages[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In the lungs of both A pleuropneumoniae- and zymosan-challenged pigs, Tulathromycin A (2.5 mg/kg, IM) promotes leukocyte apoptosis and efferocytosis and inhibites proinflammatory leukotriene B4 production, with a concurrent reduction in leukocyte necrosis relative to that of control pigs. Tulathromycin A also attenuates the degree of lung damage and lesion progression in A pleuropneumoniae-inoculated pigs[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

806.08

Formula

C₄₁H₇₉N₃O₁₂

CAS No.

217500-96-4

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (62.03 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2406 mL 6.2029 mL 12.4057 mL
5 mM 0.2481 mL 1.2406 mL 2.4811 mL
10 mM 0.1241 mL 0.6203 mL 1.2406 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.10 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.10 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.10 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Tulathromycin ATulathromycin CP 472295CP472295CP 472295CP-472295AntibioticBacterialbacterialpneumoniacattleswineleukocytesribosomeInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Tulathromycin A
Cat. No.:
HY-15662
Quantity:
MCE Japan Authorized Agent: