1. Anti-infection
  2. Bacterial

Tulathromycin A (Synonyms: Tulathromycin; CP 472295)

Cat. No.: HY-15662 Purity: >98.0%
Handling Instructions

Tulathromycin A is a macrolide antibiotic.

For research use only. We do not sell to patients.
Tulathromycin A Chemical Structure

Tulathromycin A Chemical Structure

CAS No. : 217500-96-4

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Tulathromycin A is a macrolide antibiotic. IC50 Value: 1 microg/ml (MIC90 for Pasteurella multocida) [2] Target: Antibacterial in vitro: Two highly pathogenic strains of M. bovis (with minimum inhibitory concentration values for tulathromycin of 1 and >64 microg/ml) were inoculated into 145 calves. Four days after inoculation, calves with clinical BRD were treated subcutaneously with saline or tulathromycin (2.5 mg/kg). Compared with saline, BRD-related withdrawals, peak rectal temperatures, and lung lesion scores were significantly lower for tulathromycin-treated calves (P < .01). Tulathromycin was highly effective in the treatment of BRD due to M. bovis in calves regardless of the minimum inhibitory concentration of the challenge strain (1 or >64 microg/ml) [1]. The lowest concentrations inhibiting the growth of 90% of isolates (MIC90) for tulathromycin were 2 microg/ml for Mannheimia (Pasteurella) haemolytica, 1 microg/ml for Pasteurella multocida (bovine), and 2 microg/ml for Pasteurella multocida (porcine) and ranged from 0.5 to 4 microg/ml for Histophilus somni (Haemophilus somnus) and from 4 to 16 microg/ml for Actinobacillus pleuropneumoniae [2]. in vivo: Each study randomly allocated 250 calves to receivetulathromycin at 2.5 mg/kg and 250 calves to receive either tilmicosin at 10 mg/kg (Colorado site) or florfenicol at 40 mg/kg (Idaho and Texas sites) on arrival at the feedlot. Calves were housed by treatment group in pens with 50 calves/pen [3]. The treatment groups were physiologic saline (n = 160) given SC at 0.02 ml/kg, tulathromycin (n = 320) given SC at 2.5 mg/kg, and tilmicosin (n = 320) given SC at 10 mg/kg [4].Tulathromycin is a triamilide antimicrobial that has been approved for use in the treatment and prevention of bovine respiratory disease and the treatment of swine respiratory disease. Toxicity: No adverse events related to tulathromycin were reported [4]. Clinical trial:

References
Molecular Weight

806.08

Formula

C₄₁H₇₉N₃O₁₂

CAS No.

217500-96-4

SMILES

O=C1O[[email protected]](CC)[[email protected]@](C)(O)[[email protected]](O)[[email protected]@H](C)NC[[email protected]](C)C[[email protected]@](C)(O)[[email protected]](O[[email protected]@]2([H])[[email protected]](O)[[email protected]@H](N(C)C)C[[email protected]@H](C)O2)[[email protected]@H](C)[[email protected]](O[[email protected]@]3([H])C[[email protected]@](C)(OC)[[email protected]@](CNCCC)(O)[[email protected]](C)O3)[[email protected]]1C

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 45 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Tulathromycin A
Cat. No.:
HY-15662
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