1. Anti-infection
  2. Bacterial
  3. Tulathromycin A

Tulathromycin A (Synonyms: Tulathromycin; CP 472295)

Cat. No.: HY-15662 Purity: >98.0%
Handling Instructions

Tulathromycin A is a macrolide antibiotic.

For research use only. We do not sell to patients.

Tulathromycin A Chemical Structure

Tulathromycin A Chemical Structure

CAS No. : 217500-96-4

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Based on 1 publication(s) in Google Scholar

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Tulathromycin A is a macrolide antibiotic. IC50 Value: 1 microg/ml (MIC90 for Pasteurella multocida) [2] Target: Antibacterial in vitro: Two highly pathogenic strains of M. bovis (with minimum inhibitory concentration values for tulathromycin of 1 and >64 microg/ml) were inoculated into 145 calves. Four days after inoculation, calves with clinical BRD were treated subcutaneously with saline or tulathromycin (2.5 mg/kg). Compared with saline, BRD-related withdrawals, peak rectal temperatures, and lung lesion scores were significantly lower for tulathromycin-treated calves (P < .01). Tulathromycin was highly effective in the treatment of BRD due to M. bovis in calves regardless of the minimum inhibitory concentration of the challenge strain (1 or >64 microg/ml) [1]. The lowest concentrations inhibiting the growth of 90% of isolates (MIC90) for tulathromycin were 2 microg/ml for Mannheimia (Pasteurella) haemolytica, 1 microg/ml for Pasteurella multocida (bovine), and 2 microg/ml for Pasteurella multocida (porcine) and ranged from 0.5 to 4 microg/ml for Histophilus somni (Haemophilus somnus) and from 4 to 16 microg/ml for Actinobacillus pleuropneumoniae [2]. in vivo: Each study randomly allocated 250 calves to receivetulathromycin at 2.5 mg/kg and 250 calves to receive either tilmicosin at 10 mg/kg (Colorado site) or florfenicol at 40 mg/kg (Idaho and Texas sites) on arrival at the feedlot. Calves were housed by treatment group in pens with 50 calves/pen [3]. The treatment groups were physiologic saline (n = 160) given SC at 0.02 ml/kg, tulathromycin (n = 320) given SC at 2.5 mg/kg, and tilmicosin (n = 320) given SC at 10 mg/kg [4].Tulathromycin is a triamilide antimicrobial that has been approved for use in the treatment and prevention of bovine respiratory disease and the treatment of swine respiratory disease. Toxicity: No adverse events related to tulathromycin were reported [4]. Clinical trial:

Molecular Weight







Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 45 mg/mL (55.83 mM)

*"≥" means soluble, but saturation unknown.

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2406 mL 6.2029 mL 12.4057 mL
5 mM 0.2481 mL 1.2406 mL 2.4811 mL
10 mM 0.1241 mL 0.6203 mL 1.2406 mL
*Please refer to the solubility information to select the appropriate solvent.
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Tulathromycin ATulathromycinCP 472295CP472295CP-472295BacterialInhibitorinhibitorinhibit

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