1. Anti-infection
  2. Bacterial
  3. Nucleocidin

Nucleocidin (Synonyms: 4'-Fluoro-5'-O-sulfamoyladenosine; NSC 521007)

Cat. No.: HY-100496
Handling Instructions

Nucleocidin is an antitrypanosomal antibiotic, inhibiting the transfer of labeled amino acid from S-RNA to protein.

For research use only. We do not sell to patients.

Nucleocidin Chemical Structure

Nucleocidin Chemical Structure

CAS No. : 24751-69-7

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Description

Nucleocidin is an antitrypanosomal antibiotic, inhibiting the transfer of labeled amino acid from S-RNA to protein.

IC50 & Target

Antibacterial[1].

In Vitro

Although appreciable inhibition occurrs at low concentrations of nucleocidin, it is not possible to obtain complete inhibition even at 10-3 M. An appreciable lag occurrs before any inhibition by nucleocidin is detectable, and the length of this lag period varies inversely with the concentration of nucleocidin. Similar results are obtained when nucleocidin is added to the cell-free system from reticulocytes. By contrast, essentially complete inhibition is obtained at 10-3 M puromycin, and only at the lowest concentrations is any lag detectable. It seems that nucleocidin exhibits the pattern typical of many antibiotics, i.e. it inhibits incorporation at a stage subsequent to the formation of aminoacyl-S-RNA[1].

Molecular Weight

364.31

Formula

C₁₀H₁₃FN₆O₆S

CAS No.

24751-69-7

SMILES

O[[email protected]@H]([[email protected]]([[email protected]](N1C=NC2=C1N=CN=C2N)O3)O)[[email protected]@]3(F)COS(=O)(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Nucleocidin4'-Fluoro-5'-O-sulfamoyladenosine NSC 521007NSC521007NSC 521007NSC-521007BacterialInhibitorinhibitorinhibit

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