2. Anti-infection
  3. Bacterial Antibiotic
  4. Nosiheptide

Nosiheptide  (Synonyms: Multhiomycin; RP 9671)

Cat. No.: HY-107486 Purity: 97.05%
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Nosiheptide (Multhiomycin), a thiopeptide antibiotic produced by Streptomyces actuosus, inhibits bacterial protein synthesis and bears a unique indole side ring system and regiospecific hydroxyl groups on the characteristic macrocyclic core. Nosiheptide has been widely used as a feed additive for animal growth.

For research use only. We do not sell to patients.

Nosiheptide Chemical Structure

Nosiheptide Chemical Structure

CAS No. : 56377-79-8

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 309 In-stock
Solution
10 mM * 1 mL in DMSO USD 309 In-stock
Solid
1 mg USD 83 In-stock
5 mg USD 140 In-stock
10 mg USD 230 In-stock
25 mg USD 460 In-stock
50 mg USD 700 In-stock
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Based on 1 publication(s) in Google Scholar

Nosiheptide Related Antibodies

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Description

Nosiheptide (Multhiomycin), a thiopeptide antibiotic produced by Streptomyces actuosus, inhibits bacterial protein synthesis and bears a unique indole side ring system and regiospecific hydroxyl groups on the characteristic macrocyclic core. Nosiheptide has been widely used as a feed additive for animal growth[1][2].

In Vitro

Nosiheptide exhibits extremely potent activity against all contemporary Staphylococcus aureus strains tested including multiple drug-resistant clinical isolates, with MIC values ≤ 0.25 mg/L. Nosiheptide is also highly active against Enterococcus spp and the contemporary hypervirulent BI strain of Clostridium difficile but is inactive against most Gram-negative strains tested. Time-kill analysis reveals Nosiheptide to be rapidly bactericidal against Staphylococcus aureus in a concentration- and time-dependent manner, with a nearly 2-log kill noted at 6 hours at 10X MIC. Furthermore, Nosiheptide is found to be non-cytotoxic against mammalian cells at >> 100X MIC, and its anti-Staphylococcus aureus activity is not inhibited by 20% human serum. Notably, Nosiheptide exhibits a significantly prolonged post-antibiotic effect against both healthcare- and community-associated Staphylococcus aureus compared to vancomycin[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nosiheptide Related Antibodies
In Vivo

Nosiheptide (20 mg/kg; intraperitoneal injection; injected at 1 and 8 h post-infection; female CD1 mice) provids significant protection against mortality. Ten out of 10 of the Nosiheptide-treated mice remains alive on day 3, while 6/10 of the controls died on day 1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight week old female CD1 mice injected with HA-Staphylococcus aureus strain Sanger 252[1]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection; injected at 1 and 8 h post-infection
Result: Provided significant protection against mortality.
Molecular Weight

1222.36

Formula

C51H43N13O12S6
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

OC1=C(C2=NC(C(NC(C(N)=O)=C)=O)=CS2)N=C(C3=CSC(C4NC(C5=CSC(C(CC(C(OCC6=C7C(C)=C(NC7=CC=C6)C(SC4)=O)=O)O)NC(C8=CSC(/C(NC(C(C(O)C)NC(C9=CSC%10=N9)=O)=O)=C\C)=N8)=O)=N5)=O)=N3)C%10=C1
Structure Classification
Initial Source

Streptomyces actuosus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (81.81 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8181 mL 4.0904 mL 8.1809 mL
5 mM 0.1636 mL 0.8181 mL 1.6362 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 97.05%

COA (260 KB) LCMS (270 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8181 mL 4.0904 mL 8.1809 mL 20.4522 mL
5 mM 0.1636 mL 0.8181 mL 1.6362 mL 4.0904 mL
10 mM 0.0818 mL 0.4090 mL 0.8181 mL 2.0452 mL
15 mM 0.0545 mL 0.2727 mL 0.5454 mL 1.3635 mL
20 mM 0.0409 mL 0.2045 mL 0.4090 mL 1.0226 mL
25 mM 0.0327 mL 0.1636 mL 0.3272 mL 0.8181 mL
30 mM 0.0273 mL 0.1363 mL 0.2727 mL 0.6817 mL
40 mM 0.0205 mL 0.1023 mL 0.2045 mL 0.5113 mL
50 mM 0.0164 mL 0.0818 mL 0.1636 mL 0.4090 mL
60 mM 0.0136 mL 0.0682 mL 0.1363 mL 0.3409 mL
80 mM 0.0102 mL 0.0511 mL 0.1023 mL 0.2557 mL
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Nosiheptide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nosiheptide56377-79-8Multhiomycin RP 9671RP9671RP 9671RP-9671BacterialAntibioticInhibitorinhibitorinhibit

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