1. Anti-infection
  2. Bacterial
  3. Nosiheptide

Nosiheptide (Synonyms: Multhiomycin; RP 9671)

Cat. No.: HY-107486 Purity: 97.20%
Handling Instructions

Nosiheptide (Multhiomycin), a thiopeptide antibiotic produced by Streptomyces actuosus, inhibits bacterial protein synthesis and bears a unique indole side ring system and regiospecific hydroxyl groups on the characteristic macrocyclic core. Nosiheptide has been widely used as a feed additive for animal growth.

For research use only. We do not sell to patients.

Nosiheptide Chemical Structure

Nosiheptide Chemical Structure

CAS No. : 56377-79-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 403 In-stock
Estimated Time of Arrival: December 31
5 mg USD 175 In-stock
Estimated Time of Arrival: December 31
10 mg USD 300 In-stock
Estimated Time of Arrival: December 31
25 mg USD 525 In-stock
Estimated Time of Arrival: December 31
50 mg USD 875 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Nosiheptide (Multhiomycin), a thiopeptide antibiotic produced by Streptomyces actuosus, inhibits bacterial protein synthesis and bears a unique indole side ring system and regiospecific hydroxyl groups on the characteristic macrocyclic core. Nosiheptide has been widely used as a feed additive for animal growth[1][2].

In Vitro

Nosiheptide exhibits extremely potent activity against all contemporary Staphylococcus aureus strains tested including multiple drug-resistant clinical isolates, with MIC values ≤ 0.25 mg/L. Nosiheptide is also highly active against Enterococcus spp and the contemporary hypervirulent BI strain of Clostridium difficile but is inactive against most Gram-negative strains tested. Time-kill analysis reveals Nosiheptide to be rapidly bactericidal against Staphylococcus aureus in a concentration- and time-dependent manner, with a nearly 2-log kill noted at 6 hours at 10X MIC. Furthermore, Nosiheptide is found to be non-cytotoxic against mammalian cells at >> 100X MIC, and its anti-Staphylococcus aureus activity is not inhibited by 20% human serum. Notably, Nosiheptide exhibits a significantly prolonged post-antibiotic effect against both healthcare- and community-associated Staphylococcus aureus compared to vancomycin[1].

In Vivo

Nosiheptide (20 mg/kg; intraperitoneal injection; injected at 1 and 8 h post-infection; female CD1 mice) provids significant protection against mortality. Ten out of 10 of the Nosiheptide-treated mice remains alive on day 3, while 6/10 of the controls died on day 1[1].

Animal Model: Eight week old female CD1 mice injected with HA-Staphylococcus aureus strain Sanger 252[1]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection; injected at 1 and 8 h post-infection
Result: Provided significant protection against mortality.
Molecular Weight

1222.36

Formula

C₅₁H₄₃N₁₃O₁₂S₆

CAS No.

56377-79-8

SMILES

OC1=C(C2=NC(C(NC(C(N)=O)=C)=O)=CS2)N=C(C3=CSC(C4NC(C5=CSC(C(CC(C(OCC6=C7C(C)=C(NC7=CC=C6)C(SC4)=O)=O)O)NC(C8=CSC(/C(NC(C(C(O)C)NC(C9=CSC%10=N9)=O)=O)=C\C)=N8)=O)=N5)=O)=N3)C%10=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (102.26 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8181 mL 4.0904 mL 8.1809 mL
5 mM 0.1636 mL 0.8181 mL 1.6362 mL
10 mM 0.0818 mL 0.4090 mL 0.8181 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

NosiheptideMulthiomycin RP 9671RP9671RP 9671RP-9671BacterialInhibitorinhibitorinhibit

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Nosiheptide
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