Nosiheptide
Based on 1 Customer Validation
Nosiheptide (Multhiomycin), a thiopeptide antibiotic produced by Streptomyces actuosus, inhibits bacterial protein synthesis and bears a unique indole side ring system and regiospecific hydroxyl groups on the characteristic macrocyclic core. Nosiheptide has been widely used as a feed additive for animal growth.
For research use only. We do not sell to patients.
- Purity: 98.71%
- CAS No.: 56377-79-8
- Formula: C51H43N13O12S6
- Molecular Weight:1222.36
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All Antibiotic Isoforms
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Biological Activity
Nosiheptide exhibits extremely potent activity against all contemporary Staphylococcus aureus strains tested including multiple drug-resistant clinical isolates, with MIC values ≤ 0.25 mg/L. Nosiheptide is also highly active against Enterococcus spp and the contemporary hypervirulent BI strain of Clostridium difficile but is inactive against most Gram-negative strains tested. Time-kill analysis reveals Nosiheptide to be rapidly bactericidal against Staphylococcus aureus in a concentration- and time-dependent manner, with a nearly 2-log kill noted at 6 hours at 10X MIC. Furthermore, Nosiheptide is found to be non-cytotoxic against mammalian cells at >> 100X MIC, and its anti-Staphylococcus aureus activity is not inhibited by 20% human serum. Notably, Nosiheptide exhibits a significantly prolonged post-antibiotic effect against both healthcare- and community-associated Staphylococcus aureus compared to vancomycin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Eight week old female CD1 mice injected with HA-Staphylococcus aureus strain Sanger 252[1]
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Dosage:20 mg/kg
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Administration:Intraperitoneal injection; injected at 1 and 8 h post-infection
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Result:Provided significant protection against mortality.
Chemical Information
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CAS No. 56377-79-8
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Appearance Solid
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Molecular Weight 1222.36
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Formula C51H43N13O12S6
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Color Light yellow to yellow
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SMILES
OC1=C(C2=NC(C(NC(C(N)=O)=C)=O)=CS2)N=C(C3=CSC(C4NC(C5=CSC(C(CC(C(OCC6=C7C(C)=C(NC7=CC=C6)C(SC4)=O)=O)O)NC(C8=CSC(/C(NC(C(C(O)C)NC(C9=CSC%10=N9)=O)=O)=C\C)=N8)=O)=N5)=O)=N3)C%10=C1
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Synonyms
Multhiomycin; RP 9671
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Structure Classification
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Initial Source
Streptomyces actuosus
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : 100 mg/mL (81.81 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Haste NM, et al. Activity of the thiopeptide antibiotic nosiheptide against contemporary strains of methicillin-resistant Staphylococcus aureus. J Antibiot (Tokyo). 2012 Dec;65(12):593-8. [Content Brief]
[2]. Yu Y, et al. Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide framework. ACS Chem Biol. 2009 Oct 16;4(10):855-64. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8181 mL | 4.0904 mL | 8.1809 mL | 20.4522 mL |
| 5 mM | 0.1636 mL | 0.8181 mL | 1.6362 mL | 4.0904 mL | |
| 10 mM | 0.0818 mL | 0.4090 mL | 0.8181 mL | 2.0452 mL | |
| 15 mM | 0.0545 mL | 0.2727 mL | 0.5454 mL | 1.3635 mL | |
| 20 mM | 0.0409 mL | 0.2045 mL | 0.4090 mL | 1.0226 mL | |
| 25 mM | 0.0327 mL | 0.1636 mL | 0.3272 mL | 0.8181 mL | |
| 30 mM | 0.0273 mL | 0.1363 mL | 0.2727 mL | 0.6817 mL | |
| 40 mM | 0.0205 mL | 0.1023 mL | 0.2045 mL | 0.5113 mL | |
| 50 mM | 0.0164 mL | 0.0818 mL | 0.1636 mL | 0.4090 mL | |
| 60 mM | 0.0136 mL | 0.0682 mL | 0.1363 mL | 0.3409 mL | |
| 80 mM | 0.0102 mL | 0.0511 mL | 0.1023 mL | 0.2557 mL |
Nosiheptide Related Classifications
HY-107486 Related Classifications
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