2. Anti-infection
  3. Antibiotic Bacterial
  4. IMipenem and cilastatin sodium

IMipenem and cilastatin sodium is a broad-spectrum Carbapenem Antibiotic combination. Imipenem (HY-B1369A) is a Carbapenem antibiotic. IMipenem demonstrates excellent activity against gram-positive and gram-negative aerobic and anaerobic organisms. Cilastatin (HY-A0166) is a renal Dehydropeptidase inhibitor that inhibits the metabolism of Imipenem by renal brush-border enzymes, thus increasing imipenem concentrations in urine.

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IMipenem and cilastatin sodium

IMipenem and cilastatin sodium Chemical Structure

CAS No. : 85960-17-4

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Based on 1 publication(s) in Google Scholar

IMipenem and cilastatin sodium Related Antibodies

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Description

IMipenem and cilastatin sodium is a broad-spectrum Carbapenem Antibiotic combination. Imipenem (HY-B1369A) is a Carbapenem antibiotic. IMipenem demonstrates excellent activity against gram-positive and gram-negative aerobic and anaerobic organisms. Cilastatin (HY-A0166) is a renal Dehydropeptidase inhibitor that inhibits the metabolism of Imipenem by renal brush-border enzymes, thus increasing imipenem concentrations in urine[1].

In Vivo

IMipenem and cilastatin sodium is administered by the intravenous route only[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

679.78

Formula

C28H42N5NaO9S2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

C[C@@H](O)[C@@H]1[C@H]2CC(SCCNC=N)=C(C(O)=O)N2C1=O.CC3(C)C[C@@H]3C(N/C(C([O-])=O)=C\CCCCSC[C@H](N)C(O)=O)=O.[Na+]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 20 mg/mL (29.42 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4711 mL 7.3553 mL 14.7106 mL
5 mM 0.2942 mL 1.4711 mL 2.9421 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.4711 mL 7.3553 mL 14.7106 mL 36.7766 mL
5 mM 0.2942 mL 1.4711 mL 2.9421 mL 7.3553 mL
10 mM 0.1471 mL 0.7355 mL 1.4711 mL 3.6777 mL
15 mM 0.0981 mL 0.4904 mL 0.9807 mL 2.4518 mL
20 mM 0.0736 mL 0.3678 mL 0.7355 mL 1.8388 mL
25 mM 0.0588 mL 0.2942 mL 0.5884 mL 1.4711 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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IMipenem and cilastatin sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IMipenem and cilastatin85960-17-4AntibioticBacterialpelvic infectionsrenal dehydropeptidase inhibitorgram-positive anaerobic organismsintra-abdominal infectionsgram-negative aerobic organismsrenal brush-border enzymesgram-negative anaerobic organismsPseudomonas aeruginosaantimicrobial agentgram-positive aerobic organismsInhibitorinhibitorinhibit

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