p38 MAPK-IN-11
p38 MAPK-IN-11 is a CSBP (p38 MAPK) kinase inhibitor with IC50 values of 0.15 μM (binding activity) and 0.21 μM (inhibitory activity). p38 MAPK-IN-11 shows weak inhibitory activity against PKCα kinase, with an IC50 of 7.6 μM. p38 MAPK-IN-11 inhibits the production of IL-1. p38 MAPK-IN-11 also acts as a β-lactam antibiotic potentiator, but has no antibacterial activity itself.
For research use only. We do not sell to patients.
- CAS No.: 152121-51-2
- Formula: C20H14FN3
- Molecular Weight:315.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RBL-1 | Inhibition |
53 %
Compound: 11
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Inhibitory activity against 5-lipoxygenase enzyme from RBL-1 cells at 20 uM
Inhibitory activity against 5-lipoxygenase enzyme from RBL-1 cells at 20 uM
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10.1016/0960-894X(95)00189-Z |
Antibacterial agent 342 (Compound 40) inhibits IL-1 production in human monocytes, with an IC50 of 0.30 μM[1].
Antibacterial agent 342 (Compound A65) at a concentration of 20 μM exhibits almost no inherent antibacterial activity on its own, but it effectively reduces the MIC of the β-lactam antibiotic Oxacillin (HY-B0925A) (from 256 μg/mL to 128 μg/mL)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 152121-51-2
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Molecular Weight 315.35
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Formula C20H14FN3
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SMILES
FC=1C=CC(=CC1)C=2NC(=NC2C=3C=CN=CC3)C=4C=CC=CC4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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