Nifursol
Based on 1 publication(s) in Google Scholar
Nifursol is an orally active veterinary antibiotic. Nifursol inhibits Histomonas meleagridis. Nifursol prevents histomoniasis in turkeys. Nifursol is widely used in studies of Escherichia coli gastroenteritis in Salmonella-infected poultry and aquatic animals.
For research use only. We do not sell to patients.
- Purity: 98.17%
- CAS No.: 16915-70-1
- Formula: C12H7N5O9
- Molecular Weight:365.21
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Nifursol
MoreAll Antibiotic Isoforms
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Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Broad Breasted (B.B.) Bronze and B.B. White turkeys (6 female and 6 male, specific weights not mentioned, 4-9 weeks old), histomoniasis model induced by oral administration of embryonated Heterakis gallinae ova containing Histomonas meleagridis[3]
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Dosage:0, 12.5, 25, 37.5, 50, 75, 100 ppm added to a 28 percent protein, practical-type, corn-soybean meal diet
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Administration:Dietary administration, daily, 3-5 days
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Result:Completely prevented histomoniasis mortality and morbidity at 50, 75 and 100 ppm (experiment 1).
Mostly prevented mortality and morbidity at 12.5 and 25 ppm, with only one bird receiving 25 ppm showing mild lesions (experiment 2).
Chemical Information
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CAS No. 16915-70-1
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Appearance Solid
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Molecular Weight 365.21
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Formula C12H7N5O9
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Color Light yellow to yellow
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SMILES
O=C(N/N=C/C1=CC=C([N+]([O-])=O)O1)C2=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C2O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : 50 mg/mL (136.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.85 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (285 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
[1]. Bowen TE, et al. Effect of cupric sulfate on the prophylactic efficacy of 2-acetylamino-5nitrothiazole, nifursol and ipronidazole against histomoniasis in turkeys. Poult Sci. 1971 Nov;50(6):1668-72. [Content Brief]
[2]. Jorge Barbosa, et al.Detection, accumulation, distribution, and depletion of furaltadone and nifursol residues in poultry muscle, liver, and gizzard. J Agric Food Chem. 2011 Nov 23;59(22):11927-34. [Content Brief]
[3]. Sullivan TW, et al. Prophylactic efficacy of nifursol against different levels of exposure to histomoniasis in turkeys 4 to 9 weeks of age. Poult Sci. 1972 Nov;51(6):1956-9.Sullivan TW, et al. Prophylactic efficacy of nifursol against different levels of exposure to histomoniasis in turkeys 4 to 9 weeks of age. Poult Sci. 1972 Nov;51(6):1956-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.7382 mL | 13.6908 mL | 27.3815 mL | 68.4538 mL |
| 5 mM | 0.5476 mL | 2.7382 mL | 5.4763 mL | 13.6908 mL | |
| 10 mM | 0.2738 mL | 1.3691 mL | 2.7382 mL | 6.8454 mL | |
| 15 mM | 0.1825 mL | 0.9127 mL | 1.8254 mL | 4.5636 mL | |
| 20 mM | 0.1369 mL | 0.6845 mL | 1.3691 mL | 3.4227 mL | |
| 25 mM | 0.1095 mL | 0.5476 mL | 1.0953 mL | 2.7382 mL | |
| 30 mM | 0.0913 mL | 0.4564 mL | 0.9127 mL | 2.2818 mL | |
| 40 mM | 0.0685 mL | 0.3423 mL | 0.6845 mL | 1.7113 mL | |
| 50 mM | 0.0548 mL | 0.2738 mL | 0.5476 mL | 1.3691 mL | |
| 60 mM | 0.0456 mL | 0.2282 mL | 0.4564 mL | 1.1409 mL | |
| 80 mM | 0.0342 mL | 0.1711 mL | 0.3423 mL | 0.8557 mL | |
| 100 mM | 0.0274 mL | 0.1369 mL | 0.2738 mL | 0.6845 mL |
Nifursol Related Classifications
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