1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Amoxicillin trihydrate

Amoxicillin trihydrate (Synonyms: Amoxycillin trihydrate)

Cat. No.: HY-B0467B Purity: ≥98.0%
Handling Instructions

Amoxicillin (Amoxycillin) trihydrateis an antibiotic with good oral absorption and broad spectrum antimicrobial activity. Amoxicillin trihydrateis inhibits the biosynthesis of polypeptides in the cell wall, thereby inhibiting cell growth.

For research use only. We do not sell to patients.

Amoxicillin trihydrate Chemical Structure

Amoxicillin trihydrate Chemical Structure

CAS No. : 61336-70-7

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10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
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ready for reconstitution
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5 g USD 96 In-stock
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10 g USD 114 In-stock
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Customer Review

Based on 9 publication(s) in Google Scholar

Other Forms of Amoxicillin trihydrate:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

Amoxicillin (Amoxycillin) trihydrateis an antibiotic with good oral absorption and broad spectrum antimicrobial activity. Amoxicillin trihydrateis inhibits the biosynthesis of polypeptides in the cell wall, thereby inhibiting cell growth[1][2][3].

In Vitro

Amoxicillin (Amoxycillin) trihydrate (1-100 µM; 24 hours; L. acidophilus) decreases living cells and increases degree of cell wall rupture in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Amoxicillin (Amoxycillin) trihydrate (7 mg/kg; i.h.; female ICR/Swiss mice) inhibits strain numbers and improves the survival rate of rats in 1 mg/L or less[2].
Amoxicillin (Amoxycillin) trihydrate (1.6-9.5 mg/kg; p.o.; daily, for 7 or 14 days; swiss albino mice) has against infection with chlamydia trachomatis in mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female ICR/Swiss mice[2]
Dosage: 7 mg/kg
Administration: Subcutaneous injection; every 8 h, for 24 hours
Result: Inhibited bacterial numbers in a dose-dependent manner.
Animal Model: Female ICR/Swiss mice[2]
Dosage: 7 mg/kg
Administration: Subcutaneous injection; every 8 h, for 4 days
Result: Survived all animals that were infected with organisms for which MICs were 1 mg/L or less, and with the two strains for which MICs were 2 mg/L, 20 to 40% mortality.
Animal Model: Swiss albino mice[3]
Dosage: 1.6 and 9.5 mg/kg
Administration: Oral administration; daily, for 7 or 14 days
Result: Improved the activity of Chlamydia trachomatis infection in mice.
Clinical Trial
Molecular Weight

419.45

Formula

C16H25N3O8S

CAS No.
SMILES

OC([[email protected]@H]1N(C2=O)[[email protected]]([[email protected]@H]2NC([[email protected]@H](C3=CC=C(O)C=C3)N)=O)([H])SC1(C)C)=O.[3H2O]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (23.84 mM; Need ultrasonic)

H2O : 2 mg/mL (4.77 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3841 mL 11.9204 mL 23.8407 mL
5 mM 0.4768 mL 2.3841 mL 4.7681 mL
10 mM 0.2384 mL 1.1920 mL 2.3841 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.96 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.96 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1 mg/mL (2.38 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Amoxicillin trihydrate
Cat. No.:
HY-B0467B
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