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  2. Antibiotic
    Bacterial
  3. RNPA1000

RNPA1000 

Cat. No.: HY-12824 Purity: >98.0%
Handling Instructions

RNPA1000, an antibiotic, is a potent RnpA inhibitor and inhibits RnpA-mediated cellular RNA degradation. RNPA1000 inhibits tRNA maturation with an IC50 of 175 μM. RNPA1000 displays broad-spectrum antimicrobial activities and inhibits staphylococcal and all Gram-positive bacterial pathogens activity.

For research use only. We do not sell to patients.

RNPA1000 Chemical Structure

RNPA1000 Chemical Structure

CAS No. : 359600-10-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 462 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Description

RNPA1000, an antibiotic, is a potent RnpA inhibitor and inhibits RnpA-mediated cellular RNA degradation. RNPA1000 inhibits tRNA maturation with an IC50 of 175 μM. RNPA1000 displays broad-spectrum antimicrobial activities and inhibits staphylococcal and all Gram-positive bacterial pathogens activity[1][2][3].

In Vitro

RNPA1000 displays antimicrobial activity toward Gram-positive bacteria and little or no toxicity toward human cells[2].
RNPA1000 limits S. aureus mRNA turnover and growth. RNPA1000 also limits growth of other important Gram-positive bacterial pathogens, exhibits antimicrobial efficacy against biofilm associated S. aureus and protects against the S. aureus pathogenesis in an animal model of infection[3].
RNPA1000 (IC50= 100-125 µM), does not affect the activity of the commercially available E. coli RNase HI, RNase A, RNase I or in-house purified S. aureus RNase J1 at any concentration tested (0-750 µM), but does mildly inhibit E. coli RNase III activity (IC50= 500-750 µM)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

464.31

Formula

C₂₃H₁₈BrN₃O₃

CAS No.

359600-10-5

SMILES

O=C(O)C1=CC=C(N2C(C)=C(/C=C(C#N)/C(NC3=CC=CC(Br)=C3)=O)C=C2C)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References
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Keywords:

RNPA1000RNPA 1000RNPA-1000AntibioticBacterialRnpARNAdegradationtRNAstaphylococcalGram-positivebacterialInhibitorinhibitorinhibit

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Product Name:
RNPA1000
Cat. No.:
HY-12824
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