1. Apoptosis Anti-infection
  2. Apoptosis Bacterial Antibiotic
  3. Cefatrizine

Cefatrizine  (Synonyms: BL-S-640; SK&F 60771)

Cat. No.: HY-123024
Handling Instructions

Cefatrizine (BL-S-640) is an orally active and broad-spectrum cephalosporin antibiotic. Cefatrizine is also a eEF2K inhibitor, with anti-proliferative activity in human breast cancer cells, which could induce ER stress, leading to cell death. Cefatrizine can be used in studies of cancer and bacterial infection.

For research use only. We do not sell to patients.

Cefatrizine Chemical Structure

Cefatrizine Chemical Structure

CAS No. : 51627-14-6

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Based on 1 publication(s) in Google Scholar

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Description

Cefatrizine (BL-S-640) is an orally active and broad-spectrum cephalosporin antibiotic. Cefatrizine is also a eEF2K inhibitor, with anti-proliferative activity in human breast cancer cells, which could induce ER stress, leading to cell death. Cefatrizine can be used in studies of cancer and bacterial infection[1][2].

IC50 & Target

β-lactam

 

In Vitro

Cefatrizine (0-100 µM; 24 h) causes a remarkable anti-proliferative effect on MCF-7 and MDA-MB-436 cell growth in a dose-dependent manner[1].
Cefatrizine (30 µM; 12 h) induces ER stress in breast cancer cells[1].
Cefatrizine (12, 24, 36 h) increases level of CHOP (marker of ER stress induced apoptosis) and promotes expressions of core proteins in eEF2K-modulated ER stress pathways (Bip, p-PERK, XBP-1S and p-JNK) in MCF-7 and MDA-MB-436 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: MCF-7, MDA-MB-436 cells
Concentration: 0-100 µM
Incubation Time: 24 h
Result: Led to a remarkable anti-proliferative effect on cells and resulted in almost 50% inhibition in the MCF-7 and MDA-MB-436 cells when at 33 µM and 29 µM.

Cell Viability Assay[1]

Cell Line: MCF-7, MDA-MB-436 cells
Concentration: 30 µM
Incubation Time: 12 h
Result: Led to massive cytoplasmic vacuolization.
In Vivo

Cefatrizine (BL-S-640) (0.2, 1, 5, 25 mg/kg; p.o.; 4 times daily for 3 days) reduces the number of infecting organisms in the bladder and the kidneys in P. mirabilis intracystically infected model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MaleSwiss-Webster mice (19-21 g; P. mirabilis intracystically infected model)[2].
Dosage: 0.2, 1, 5, 25 mg/kg
Administration: Oral administration; 4 times daily for 3 days.
Result: Reduced the number of infecting organisms to less than 1,000 in the bladder when 1 mg/kg, and in the kidneys when 0.2 mg/kg.
Molecular Weight

462.50

Formula

C18H18N6O5S2

CAS No.
SMILES

O=C(O)C(N1[C@@]([H])([C@@H](C1=O)NC([C@@H](C2=CC=C(C=C2)O)N)=O)SC3)=C3CSC4=CNN=N4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (540.54 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1622 mL 10.8108 mL 21.6216 mL
5 mM 0.4324 mL 2.1622 mL 4.3243 mL
View the Complete Stock Solution Preparation Table

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.1622 mL 10.8108 mL 21.6216 mL 54.0541 mL
5 mM 0.4324 mL 2.1622 mL 4.3243 mL 10.8108 mL
10 mM 0.2162 mL 1.0811 mL 2.1622 mL 5.4054 mL
15 mM 0.1441 mL 0.7207 mL 1.4414 mL 3.6036 mL
20 mM 0.1081 mL 0.5405 mL 1.0811 mL 2.7027 mL
25 mM 0.0865 mL 0.4324 mL 0.8649 mL 2.1622 mL
30 mM 0.0721 mL 0.3604 mL 0.7207 mL 1.8018 mL
40 mM 0.0541 mL 0.2703 mL 0.5405 mL 1.3514 mL
50 mM 0.0432 mL 0.2162 mL 0.4324 mL 1.0811 mL
60 mM 0.0360 mL 0.1802 mL 0.3604 mL 0.9009 mL
80 mM 0.0270 mL 0.1351 mL 0.2703 mL 0.6757 mL
100 mM 0.0216 mL 0.1081 mL 0.2162 mL 0.5405 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Cefatrizine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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