51627-14-6
Chemical Structure
Cefatrizine
Synonym(s): BL-S-640; SK&F 60771
- CAS No.: 51627-14-6
- Formula:C18H18N6O5S2
- Molecular Weight:462.50
IUPAC Name: (6R,7R)-3-(((1H-1,2,3-triazol-4-yl)thio)methyl)-7-((R)-2-amino-2-(4-hydroxyphenyl)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
InChIKey: UOCJDOLVGGIYIQ-PBFPGSCMSA-N
SMILES: O=C(O)C(N1[C@@]([H])([C@@H](C1=O)NC([C@@H](C2=CC=C(C=C2)O)N)=O)SC3)=C3CSC4=CNN=N4
Biological Activity: Cefatrizine (BL-S-640) is an orally active and broad-spectrum cephalosporin antibiotic. Cefatrizine is also a eEF2K inhibitor, with anti-proliferative activity in human breast cancer cells, which could induce ER stress, leading to cell death. Cefatrizine can be used in studies of cancer and bacterial infection[1][2].
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Cefatrizine | Cefatrizine (BL-S-640) is an orally active and broad-spectrum cephalosporin antibiotic. Cefatrizine is also a eEF2K inhibitor, with anti-proliferative activity in human breast cancer cells, which could induce ER stress, leading to cell death. Cefatrizine can be used in studies of cancer and bacterial infection. | |||||||||||||||||||||
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- [1]. Yao Z, et al. Integrative bioinformatics and proteomics-based discovery of an eEF2K inhibitor (cefatrizine) with ER stress modulation in breast cancer cells. Mol Biosyst. 2016 Mar;12(3):729-36. [Content Brief]
- [2]. Leitner F, et al. BL-S640, a cephalosporin with a broad spectrum of antibacterial activity: bioavailability and therapeutic properties in rodents. Antimicrob Agents Chemother. 1975 Mar;7(3):306-10. [Content Brief]
Keywords
