Demeclocycline calcium
Based on 2 publication(s) in Google Scholar
Demeclocycline calcium is an orally active tetracycline antibiotic that inhibits the binding of aminoacyl tRNA by binding to the 30S ribosomal subunit, thereby affecting protein synthesis. Demeclocycline calcium exhibits antibacterial activity against a broad spectrum of bacterial infections.
For research use only. We do not sell to patients.
- CAS No.: 17146-81-5
- Formula: C21H21ClN2O8.1/2Ca1
- Molecular Weight:484.89
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Publications Citing Use of MedChemExpress (MCE) Demeclocycline calcium
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Biological Activity
Demeclocycline (0-100 μM; 24 h) calcium treatment reduces AQP2 abundance in mpkCCD cells[3].
Demeclocycline (10 μM; 24 h) calcium treatment promotes the activity of monocytes and macrophages[4].
Demeclocycline (1-10 μM; 72 h) calcium treatment directly affects the growth of brain tumorinitiating cells[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MpkCCD cells
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Concentration:0-100 μM
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Incubation Time:24 hours
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Result:Decreased AQP2 abundance in mpkCCD cells, with significant effects at 50 μM.
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Cell Line:Mouse bone marrow derived macrophages and monocytes
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Concentration:10 μM
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Incubation Time:24 hours
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Result:Enhanced TNF-α production and modulated monocyte functions.
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Cell Line:Brain tumorinitiating cells
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Concentration:1, 5, and 10 μM
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Incubation Time:72 hours
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Result:Inhibited cells growth in two ways: using monocytes as an intermediary, and directly by affecting the proliferation and sphere-forming capacity of brain tumorinitiating cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats induced with hyponatremia[3]
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Dosage:40 mg/kg
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Administration:Intraperitoneal injection; 40 mg/kg; once daily; 48 hours
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Result:Increased urine volume, decreased urine osmolality, and caused a significantly increased fractional excretion of water.
Indicated the effect in the renal inner medulla for AQP2 and AC5/6 specifically, and not secondary toxicity effect.
Chemical Information
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CAS No. 17146-81-5
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Molecular Weight 484.89
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Formula C21H21ClN2O8.1/2Ca1
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SMILES
O[C@]12[C@](C[C@@]3([H])C(C(C4=C([O-])C=CC(Cl)=C4[C@H]3O)=O)=C2O)([H])[C@@H](C(O)=C(C1=O)C(N)=O)N(C)C.[Ca+2].[0.5]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
Purity & Documentation
References
[1]. I Chopra, et al. Tetracyclines, molecular and clinical aspects. J Antimicrob Chemother. 1992 Mar;29(3):245-77. [Content Brief]
[2]. D Schnappinger, et al. Tetracyclines: antibiotic action, uptake, and resistance mechanisms. Arch Microbiol. 1996 Jun;165(6):359-69. [Content Brief]
[3]. Marleen L A Kortenoeven, et al. Demeclocycline attenuates hyponatremia by reducing aquaporin-2 expression in the renal inner medulla. Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1705-18. [Content Brief]
[4]. Susobhan Sarkar, et al. Demeclocycline Reduces the Growth of Human Brain Tumor-Initiating Cells: Direct Activity and Through Monocytes. Front Immunol. 2020 Feb 21;11:272. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Demeclocycline calcium Related Classifications
HY-121268A Related Classifications
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