2. Anti-infection
  3. Bacterial Antibiotic
  4. Azidamfenicol

Azidamfenicol is a broad-spectrum chloramphenicol-like antibiotic. Azidamfenicol inhibits ribosomal peptidyltransferase (Ki=22 μM). Azidamfenicol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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Azidamfenicol

Azidamfenicol Chemical Structure

CAS No. : 13838-08-9

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Based on 1 publication(s) in Google Scholar

Azidamfenicol Related Antibodies

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Description

Azidamfenicol is a broad-spectrum chloramphenicol-like antibiotic. Azidamfenicol inhibits ribosomal peptidyltransferase (Ki=22 μM)[1]. Azidamfenicol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Molecular Weight

295.25

Formula

C11H13N5O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1)CN=[N+]=[N-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (338.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3870 mL 16.9348 mL 33.8696 mL
5 mM 0.6774 mL 3.3870 mL 6.7739 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3870 mL 16.9348 mL 33.8696 mL 84.6740 mL
5 mM 0.6774 mL 3.3870 mL 6.7739 mL 16.9348 mL
10 mM 0.3387 mL 1.6935 mL 3.3870 mL 8.4674 mL
15 mM 0.2258 mL 1.1290 mL 2.2580 mL 5.6449 mL
20 mM 0.1693 mL 0.8467 mL 1.6935 mL 4.2337 mL
25 mM 0.1355 mL 0.6774 mL 1.3548 mL 3.3870 mL
30 mM 0.1129 mL 0.5645 mL 1.1290 mL 2.8225 mL
40 mM 0.0847 mL 0.4234 mL 0.8467 mL 2.1169 mL
50 mM 0.0677 mL 0.3387 mL 0.6774 mL 1.6935 mL
60 mM 0.0564 mL 0.2822 mL 0.5645 mL 1.4112 mL
80 mM 0.0423 mL 0.2117 mL 0.4234 mL 1.0584 mL
100 mM 0.0339 mL 0.1693 mL 0.3387 mL 0.8467 mL
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Azidamfenicol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Azidamfenicol13838-08-9BacterialAntibioticribosomalpeptidyltransferasebacteriaGram-negativeGram-positiveInhibitorinhibitorinhibit

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