Puromycin-d3 dihydrochloride
Based on 3 publication(s) in Google Scholar
Puromycin-d3 (dihydrochloride) is the deuterium labeled Puromycin dihydrochloride. Puromycin dihydrochloride (CL13900 dihydrochloride), an aminonucleoside antibiotic, inhibits protein synthesis.
For research use only. We do not sell to patients.
- Purity: 98.0%
- Formula: C22H28D3Cl2N7O5
- Molecular Weight:547.45
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Puromycin-d3 dihydrochloride
MoreAll Antibiotic Isoforms
More
Biological Activity
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Aminoglycoside |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 58-58-2
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Appearance Solid
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Molecular Weight 547.45
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Formula C22H28D3Cl2N7O5
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Color Off-white to light yellow
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SMILES
OC[C@@H]1[C@@H](NC([C@@H](N)CC2=CC=C(OC([2H])([2H])[2H])C=C2)=O)[C@H]([C@H](N3C=NC4=C3N=CN=C4N(C)C)O1)O.[H]Cl.[H]Cl
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Synonyms
CL13900-d3 dihydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (3)
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Journal Impact Factor
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Most Recent
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Proc Natl Acad Sci U S A
The moonlighting function of glycolytic enzyme enolase-1 promotes choline phospholipid metabolism and tumor cell proliferation. [Abstract]2023 Apr 11;120(15):e2209435120. PMID: 37011206 -
mBio
Infectious bursal disease virus VP5 triggers host shutoff in a transcription-dependent manner. [Abstract]2024 Mar 13;15(3):e0343323. PMID: 38289089 -
Int J Biochem Cell Biol
UBC9 stabilizes PFKFB3 to promote aerobic glycolysis and proliferation of glioblastoma cells. [Abstract]2023 Dec:165:106491. PMID: 38149579
Solvent & Solubility
Methanol : 250 mg/mL (456.66 mM; Need ultrasonic)
DMSO : 50 mg/mL (91.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : 5 mg/mL (9.13 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Nathans D, et al. Puromycin inhibition of protein synthesis: incorporation of puromycin intopeptide chains. Proc Natl Acad Sci U S A. 1964 Apr;51:585-92. [Content Brief]
[3]. Miyamoto-Sato E, et al. Specific bonding of puromycin to full-length protein at the C-terminus. Nucleic Acids Res. 2000 Mar 1;28(5):1176-82. [Content Brief]
[4]. Schmidt EK, et al. SUnSET, a nonradioactive method to monitor protein synthesis. Nat Methods. 2009 Apr;6(4):275-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| Ethanol / DMSO / Methanol | 1 mM | 1.8267 mL | 9.1333 mL | 18.2665 mL | 45.6663 mL |
| 5 mM | 0.3653 mL | 1.8267 mL | 3.6533 mL | 9.1333 mL | |
| DMSO / Methanol | 10 mM | 0.1827 mL | 0.9133 mL | 1.8267 mL | 4.5666 mL |
| 15 mM | 0.1218 mL | 0.6089 mL | 1.2178 mL | 3.0444 mL | |
| 20 mM | 0.0913 mL | 0.4567 mL | 0.9133 mL | 2.2833 mL | |
| 25 mM | 0.0731 mL | 0.3653 mL | 0.7307 mL | 1.8267 mL | |
| 30 mM | 0.0609 mL | 0.3044 mL | 0.6089 mL | 1.5222 mL | |
| 40 mM | 0.0457 mL | 0.2283 mL | 0.4567 mL | 1.1417 mL | |
| 50 mM | 0.0365 mL | 0.1827 mL | 0.3653 mL | 0.9133 mL | |
| 60 mM | 0.0304 mL | 0.1522 mL | 0.3044 mL | 0.7611 mL | |
| 80 mM | 0.0228 mL | 0.1142 mL | 0.2283 mL | 0.5708 mL | |
| Methanol | 100 mM | 0.0183 mL | 0.0913 mL | 0.1827 mL | 0.4567 mL |
Puromycin-d3 dihydrochloride Related Classifications
HY-B1743AS Related Classifications
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