Puromycin-d3 dihydrochloride
Based on 3 publication(s) in Google Scholar
Puromycin-d3 (dihydrochloride) is the deuterium labeled Puromycin dihydrochloride. Puromycin dihydrochloride (CL13900 dihydrochloride), an aminonucleoside antibiotic, inhibits protein synthesis.
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- 純度 : 98.0%
- 分子式: C22H28D3Cl2N7O5
- 分子量:547.45
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保管条件:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Puromycin-d3 dihydrochloride
MoreAntibiotic アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
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Aminoglycoside |
体外実験
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
アプリケーション
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
化学情報
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非標識Cas 58-58-2
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性状 Solid
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分子量 547.45
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分子式 C22H28D3Cl2N7O5
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Color Off-white to light yellow
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SMILES
OC[C@@H]1[C@@H](NC([C@@H](N)CC2=CC=C(OC([2H])([2H])[2H])C=C2)=O)[C@H]([C@H](N3C=NC4=C3N=CN=C4N(C)C)O1)O.[H]Cl.[H]Cl
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別名
CL13900-d3 dihydrochloride
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (3)
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Journal Impact Factor
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Most Recent
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Proc Natl Acad Sci U S A
The moonlighting function of glycolytic enzyme enolase-1 promotes choline phospholipid metabolism and tumor cell proliferation. [Abstract]2023 Apr 11;120(15):e2209435120. PMID: 37011206 -
mBio
Infectious bursal disease virus VP5 triggers host shutoff in a transcription-dependent manner. [Abstract]2024 Mar 13;15(3):e0343323. PMID: 38289089 -
Int J Biochem Cell Biol
UBC9 stabilizes PFKFB3 to promote aerobic glycolysis and proliferation of glioblastoma cells. [Abstract]2023 Dec:165:106491. PMID: 38149579
溶剤 & 溶解度
体外:
Methanol : 250 mg/mL (456.66 mM; Need ultrasonic)
DMSO : 50 mg/mL (91.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : 5 mg/mL (9.13 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Nathans D, et al. Puromycin inhibition of protein synthesis: incorporation of puromycin intopeptide chains. Proc Natl Acad Sci U S A. 1964 Apr;51:585-92. [Content Brief]
[3]. Miyamoto-Sato E, et al. Specific bonding of puromycin to full-length protein at the C-terminus. Nucleic Acids Res. 2000 Mar 1;28(5):1176-82. [Content Brief]
[4]. Schmidt EK, et al. SUnSET, a nonradioactive method to monitor protein synthesis. Nat Methods. 2009 Apr;6(4):275-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / DMSO / Methanol | 1 mM | 1.8267 mL | 9.1333 mL | 18.2665 mL | 45.6663 mL |
| 5 mM | 0.3653 mL | 1.8267 mL | 3.6533 mL | 9.1333 mL | |
| DMSO / Methanol | 10 mM | 0.1827 mL | 0.9133 mL | 1.8267 mL | 4.5666 mL |
| 15 mM | 0.1218 mL | 0.6089 mL | 1.2178 mL | 3.0444 mL | |
| 20 mM | 0.0913 mL | 0.4567 mL | 0.9133 mL | 2.2833 mL | |
| 25 mM | 0.0731 mL | 0.3653 mL | 0.7307 mL | 1.8267 mL | |
| 30 mM | 0.0609 mL | 0.3044 mL | 0.6089 mL | 1.5222 mL | |
| 40 mM | 0.0457 mL | 0.2283 mL | 0.4567 mL | 1.1417 mL | |
| 50 mM | 0.0365 mL | 0.1827 mL | 0.3653 mL | 0.9133 mL | |
| 60 mM | 0.0304 mL | 0.1522 mL | 0.3044 mL | 0.7611 mL | |
| 80 mM | 0.0228 mL | 0.1142 mL | 0.2283 mL | 0.5708 mL | |
| Methanol | 100 mM | 0.0183 mL | 0.0913 mL | 0.1827 mL | 0.4567 mL |
Puromycin-d3 dihydrochloride 関連分類
HY-B1743AS 関連分類
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