Amphotericin B methyl ester

Name: Amphotericin B methyl ester
Brand: MedChemExpress
SKU: HY-135327
Rating: 4.5 (1 reviews)

Cat. No.: HY-135327 Purity: ≥81.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Amphotericin B methyl ester is the methyl ester derivative of the polyene antibiotic Amphotericin B (A634250). Amphotericin B methyl ester is the cholesterol-binding compound possesses significant antifungal activity. Amphotericin B methyl ester disrupts HIV-1 particle production and potently inhibits HIV-1 replication.

For research use only. We do not sell to patients.

Amphotericin B methyl ester Chemical Structure

CAS No. : 36148-89-7

Size	Price	Stock	Quantity
1 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Amphotericin B methyl ester:

Amphotericin B methyl ester hydrochloride Get quote

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Amphotericin B methyl ester inhibits HIV-1 particle production with no significant effect on Gag binding to the plasma membrane, Gag association with lipid rafts, or Gag multimerization^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

938.11

Formula

C₄₈H₇₅NO₁₇

CAS No.

36148-89-7

Appearance

Solid

Color

Light yellow to yellow

SMILES

COC([C@H]1[C@@]2([H])O[C@](O)(C[C@H](C[C@H]([C@@H](CC[C@H](C[C@H](CC(O[C@H]([C@@H]([C@H](O)[C@@H](C)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](O[C@@]3([H])[C@H]([C@H]([C@H](O)[C@@H](C)O3)N)O)C2)C)C)=O)O)O)O)O)O)C[C@@H]1O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (53.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0660 mL	5.3299 mL	10.6597 mL
5 mM	0.2132 mL	1.0660 mL	2.1319 mL
10 mM	0.1066 mL	0.5330 mL	1.0660 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥81.0%

Select Batch:

Data Sheet (273 KB) SDS (0 KB)

COA (249 KB) Elemental Analysis Report (108 KB)

Handling Instructions (2659 KB)

References

[1]. Waheed AA, et al. Inhibition of human immunodeficiency virus type 1 assembly and release by the cholesterol-binding compound amphotericin B methyl ester: evidence for Vpu dependence. J Virol. 2008 Oct;82(19):9776-81. [Content Brief]

[2]. Keim GR, et al. Comparative toxicological studies of amphotericin B methyl ester and amphotericin B in mice, rats, and dogs. ntimicrob Agents Chemother. 1976 Oct;10(4):687-90. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0660 mL	5.3299 mL	10.6597 mL	26.6493 mL
	5 mM	0.2132 mL	1.0660 mL	2.1319 mL	5.3299 mL
	10 mM	0.1066 mL	0.5330 mL	1.0660 mL	2.6649 mL
	15 mM	0.0711 mL	0.3553 mL	0.7106 mL	1.7766 mL
	20 mM	0.0533 mL	0.2665 mL	0.5330 mL	1.3325 mL
	25 mM	0.0426 mL	0.2132 mL	0.4264 mL	1.0660 mL
	30 mM	0.0355 mL	0.1777 mL	0.3553 mL	0.8883 mL
	40 mM	0.0266 mL	0.1332 mL	0.2665 mL	0.6662 mL
	50 mM	0.0213 mL	0.1066 mL	0.2132 mL	0.5330 mL