Pibrozelesin
Pibrozelesin (KW 2189 free base) is the derivative of antibiotic Duocarmycin B2. Pibrozelesin exhibits antitumor activity, inhibits proliferation of cell H69 with an IC50 of 1.9 μM. Pibrozelesin induces the DNA strand breaks upon activation via carboxyl esterase.
For research use only. We do not sell to patients.
- CAS No.: 154889-68-6
- Formula: C32H36BrN5O8
- Molecular Weight:698.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
18.1 ng/mL
Compound: 7
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Concentration required to inhibit the growth of HeLaS3 human uterine cervix carcinoma cells by 50%
Concentration required to inhibit the growth of HeLaS3 human uterine cervix carcinoma cells by 50%
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[PMID: 10212131] |
| HeLa | IC50 |
18.1 ng/mL
Compound: 7
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Concentration required for 50% inhibition of human uterine Cervix Carcinoma cells (HeLaS3)
Concentration required for 50% inhibition of human uterine Cervix Carcinoma cells (HeLaS3)
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10.1016/S0960-894X(97)00288-6 |
Chemical Information
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CAS No. 154889-68-6
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Molecular Weight 698.56
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Formula C32H36BrN5O8
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SMILES
BrC[C@H]1C2=C(N(C1)C(C(NC3=C4OC)=CC3=CC(OC)=C4OC)=O)C=C(OC(N5CCN(CC5)C)=O)C6=C2C(C(OC)=O)=C(C)N6
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Synonyms
KW 2189 free base
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pibrozelesin Related Classifications
HY-19137 Related Classifications
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