Kazusamycin B
Kazusamycin B is an antibiotic that could be isolated from the fermentation broth of Streptomyces sp. No. 81-484. Kazusamycin B inhibits cell growth and arrests cell cycle at G1 phase. Kazusamycin B can be used in research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 107140-30-7
- Formula: C32H46O7
- Molecular Weight:542.70
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Kazusamycin B (PD 124895; 5 ng/mL; 24 h; 1210 cells) has cell cytotoxicity in a time-dependent manner and arrests cell cycle at G1 phase[2].
Kazusamycin B (5-50 ng/mL; 0-6 h; 1210 cells) B inhibits RNA synthesis moderately but specifically at 2 hours[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:1210 cells
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Concentration:5 ng/mL
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Incubation Time:24 h
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Result:Arrested cell cycle at G1 phase at 4 hours.
Chemical Information
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CAS No. 107140-30-7
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Molecular Weight 542.70
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Formula C32H46O7
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SMILES
O=C(/C=C(CC(C(C(C(C(/C=C(/C=C/CC(/C=C(/C=C/C1C(C=CC(O1)=O)C)C)C)C)CO)=O)C)O)C)\C)O
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Synonyms
PD 124895; CL-1957E
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Funaishi K, et, al. Kazusamycin B, a novel antitumor antibiotic. J Antibiot (Tokyo). 1987 Jun;40(6):778-85. [Content Brief]
[2]. Takamiya K, et, al. The effect of kazusamycin B on the cell cycle and morphology of cultured L1210 cells. J Antibiot (Tokyo). 1988 Dec;41(12):1854-61. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Kazusamycin B Related Classifications
HY-118331 Related Classifications
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