1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Penicillin V Potassium

Penicillin V Potassium (Synonyms: Phenoxymethylpenicillin potassium salt)

Cat. No.: HY-B0975 Purity: 98.08%
Handling Instructions

Penicillin V Potassium (Phenoxymethylpenicillin potassium salt) is an orally active antibiotic. Penicillin V Potassium inhibits the growth of Streptococci, C. difficile and S. aureus. Penicillin V Potassium can be used for the research of otitis, sinusitis, pharyngitis and tonsillitis.

For research use only. We do not sell to patients.

Penicillin V Potassium Chemical Structure

Penicillin V Potassium Chemical Structure

CAS No. : 132-98-9

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Estimated Time of Arrival: December 31
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Description

Penicillin V Potassium (Phenoxymethylpenicillin potassium salt) is an orally active antibiotic. Penicillin V Potassium inhibits the growth of Streptococci, C. difficile and S. aureus. Penicillin V Potassium can be used for the research of otitis, sinusitis, pharyngitis and tonsillitis[1][2][3][4].

In Vitro

Penicillin V (0.002-8.0 mg/L) inhibits the growth of Streptococci, with the minimum inhibitory concentrations (MICs) of 0.004-0.008 mg/L[2].
Penicillin V (0.002-8.0 mg/L) inhibits the growth of C. difficile, with a MIC90 of 8 mg/L[3].
Penicillin V (0.004-0.063 mg/L; 18 h) inhibits the growth of Staphylococcus aureus, with a MIC of 0.016 mg/L[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Penicillin V (0.063-0.25 mg/kg; a single s.c.) inhibits the outgrowth of S. aureus in mice thigh muscle[4].
Penicillin V (100 mg/kg; p.o. once daily for 5 d) avoids the fulminant infection of acute purulent otitis media (AOM) in rats[5].
Penicillin V (2 mg/kg; a single s.c.) exhibits the plasma half-life (61 min) and mean AUC (0.47 mg/L•h)[4][4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Specific pathogen free (SPF) male Swiss mice (20-25 g) are inoculated S. aureus[4]
Dosage: 0.063, 0.13, 0.25 mg/kg
Administration: A single s.c.
Result: Decreased the number of CFU (1.34×107 counts/mL) compared to controls (3.5×107 counts/mL) at the dose of 0.25 mg/kg.
Clinical Trial
Molecular Weight

388.48

Formula

C16H17KN2O5S

CAS No.
SMILES

O=C(O[K])[[email protected]@H](C(C)(C)S[[email protected]]1([H])[[email protected]@H]2NC(COC3=CC=CC=C3)=O)N1C2=O

Structure Classification
Source

strains of Penicillium chrysogenum

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 12 mg/mL (30.89 mM; Need ultrasonic)

H2O : 6 mg/mL (15.44 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5741 mL 12.8707 mL 25.7414 mL
5 mM 0.5148 mL 2.5741 mL 5.1483 mL
10 mM 0.2574 mL 1.2871 mL 2.5741 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (257.41 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.2 mg/mL (3.09 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.2 mg/mL (3.09 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.2 mg/mL (3.09 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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  • Molarity Calculator

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Penicillin V Potassium
Cat. No.:
HY-B0975
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