PKZ18
PKZ18 is an antibiotic and inhibits bacterial growth, with MIC values of 32-64 μg/mL against most Gram-positive bacteria. PKZ18 inhibits in vivo transcription and translation of glycyl-tRNA synthetase mRNA. PKZ18 selectively targets stem I specifier loops in Gram-positive bacteria and directly reduces T-box transcriptional read-through of the associated genes. PKZ18 prevents the codon-anticodon reading required for tRNA binding and is refractory to resistance.
For research use only. We do not sell to patients.
- CAS No.: 849658-87-3
- Formula: C22H26N2O3S
- Molecular Weight:398.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Biological Activity
Chemical Information
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CAS No. 849658-87-3
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Molecular Weight 398.52
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Formula C22H26N2O3S
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SMILES
CC(S1)=C(C2=CC=C(C=C2)C(C)C)N=C1NC([C@@H]3[C@@H]([C@]4([H])C[C@@]3([H])CC4)C(O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PKZ18 Related Classifications
HY-169810 Related Classifications
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