849658-87-3
Chemical Structure
PKZ18
- CAS No.: 849658-87-3
- Formula:C22H26N2O3S
- Molecular Weight:398.52
InChIKey: HWHYSSATNZEECJ-VSZNYVQBSA-N
SMILES: CC(S1)=C(C2=CC=C(C=C2)C(C)C)N=C1NC([C@@H]3[C@@H]([C@]4([H])C[C@@]3([H])CC4)C(O)=O)=O
Biological Activity: PKZ18 is an antibiotic and inhibits bacterial growth, with MIC values of 32-64 μg/mL against most Gram-positive bacteria. PKZ18 inhibits in vivo transcription and translation of glycyl-tRNA synthetase mRNA. PKZ18 selectively targets stem I specifier loops in Gram-positive bacteria and directly reduces T-box transcriptional read-through of the associated genes. PKZ18 prevents the codon-anticodon reading required for tRNA binding and is refractory to resistance[1][2].
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PKZ18 | PKZ18 is an antibiotic and inhibits bacterial growth, with MIC values of 32-64 μg/mL against most Gram-positive bacteria. PKZ18 inhibits in vivo transcription and translation of glycyl-tRNA synthetase mRNA. PKZ18 selectively targets stem I specifier loops in Gram-positive bacteria and directly reduces T-box transcriptional read-through of the associated genes. PKZ18 prevents the codon-anticodon reading required for tRNA binding and is refractory to resistance. | |||||||||||||||||||||
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