Cat. No.: HY-128932

Cefminox sodium

(Synonyms: MT-141)

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

Cefminox sodium (MT-141) is a semisynthetic cephamycin, which exhibits antibacterial activity. Cefminox sodium is a broad-spectrum, bactericidal cephalosporin antibiotic. Cefminox sodium also acts as a dual agonist of prostacyclin receptor (IP) and PPARγ. Cefminox sodium upregulates cAMP production and PTEN expression and inhibits Akt/mTOR signaling. Cefminox sodium also prevents pulmonary arterial hypertension in rat model.

For research use only. We do not sell to patients.

Purity: 99.83%
CAS No.: 75498-96-3
Formula: C₁₆H₂₀N₇NaO₇S₃
Molecular Weight:541.56

Storage:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Cefminox sodium Chemical Structure

CAS No.: 75498-96-3

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]^[2]

PPARγ

IP Receptor

Bacterial

All Antibiotic Isoforms :

All PPAR Isoforms :

All Prostaglandin Receptor Isoforms :

All Akt Isoforms :

All mTOR Isoforms :

In Vitro

Cefminox sodium (Compound MT-141) (0.1-800 μg/mL) is more active against gram-negative and anaerobic bacteria than against gram-positive bacteria^[1].
Cefminox sodium (10-50 μM, 48 h) significantly inhibits the hypoxia-induced cell proliferation dose-dependently in primary pulmonary artery smooth muscle cells (PASMCs) through the enhancement of both IP and PPARγ activities^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:

Primary pulmonary artery smooth muscle cells (PASMCs)
Concentration:

10 and 50 μM
Incubation Time:

48 h
Result:

Increased PTEN mRNA levels.
Increased PTEN protein levels in both normoxic and hypoxic conditions.
Inhibited the Akt/mTOR signaling pathway through elevation of PTEN protein levels.
Inhibited cell growth by up-regulation PTEN expression and inhibiting Akt/mTOR signaling in PASMCs under hypoxic conditions.

In Vivo

Cefminox sodium (Compound MT-141) (2-480 mg/kg, s.c., single dose) shows the highest efficacy against strains of Escherichia coli, Klebsiella pneumoniae, Salmonella enteritidis, Proteus morganii, Proteus rettgeri, Proteus vulgaris, Yersinia enterocolitica, Psudomonas cepacia, and Clostridium perfringens in female Slc:ddY mice model^[1].
Cefminox sodium (1-1000 mg/kg, s.c., single dose) gives dose-related serum levels in male Slc:ddY mice^[1].
Cefminox sodium (160-320 mg/kg/day, i.v., single dose) significantly decreases mean pulmonary artery pressure (mPAP) in male SD rats with hypoxia-induced pulmonary hypertension (HPH)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Adult male Sprague Dawley (SD) rats (150-200 g) with hypoxia-induced pulmonary hypertension (HPH)^[2]
Dosage:

160 and 320 mg/kg/day
Administration:

Intravenous injection (i.v.) in tail, single dose
Result:

Significantly decreased mean pulmonary artery pressure (mPAP) dose-dependently.
Significantly reversed hypoxia-induced pulmonary artery remodeling by decreasing the number of smooth muscle cells.
Increased the expression of PTEN compared with that in the normoxia or hypoxia (no treatment) groups.

Chemical Information

CAS No. 75498-96-3
Appearance Solid
Molecular Weight 541.56
Formula C₁₆H₂₀N₇NaO₇S₃
Color White to off-white
SMILES

O=C(C(N12)=C(CSC3=NN=NN3C)CS[C@]2([H])[C@](OC)(NC(CSC[C@@H](N)C(O)=O)=O)C1=O)O[Na]
Synonyms

MT-141
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (1)

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Heliyon

Cefminox sodium alleviates the high-fat high-sugar-fed mice's hepatic fatty accumulation via multiple pathways. [Abstract]

2023 Nov 7;9(11):e21973. PMID: 38027801

Solvent & Solubility

In Vitro:

H₂O : 83.33 mg/mL (153.87 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.8465 mL

9.2326 mL

18.4652 mL

5 mM

0.3693 mL

1.8465 mL

3.6930 mL

10 mM

0.1847 mL

0.9233 mL

1.8465 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 50 mg/mL (92.33 mM); Clear solution; Need ultrasonic

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Inouye S, et al. In vitro and in vivo antibacterial activities of MT-141, a new semisynthetic cephamycin, compared with those of five cephalosporins. Antimicrob Agents Chemother. 1984 Nov;26(5):722-9. [Content Brief]

[2]. Xia J, et al. Cefminox, a Dual Agonist of Prostacyclin Receptor and Peroxisome Proliferator-Activated Receptor-Gamma Identified by Virtual Screening, Has Therapeutic Efficacy against Hypoxia-Induced Pulmonary Hypertension in Rats. Front Pharmacol. 2018 Feb 23;9:134. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	1.8465 mL	9.2326 mL	18.4652 mL	46.1629 mL
	5 mM	0.3693 mL	1.8465 mL	3.6930 mL	9.2326 mL
	10 mM	0.1847 mL	0.9233 mL	1.8465 mL	4.6163 mL
	15 mM	0.1231 mL	0.6155 mL	1.2310 mL	3.0775 mL
	20 mM	0.0923 mL	0.4616 mL	0.9233 mL	2.3081 mL
	25 mM	0.0739 mL	0.3693 mL	0.7386 mL	1.8465 mL
	30 mM	0.0616 mL	0.3078 mL	0.6155 mL	1.5388 mL
	40 mM	0.0462 mL	0.2308 mL	0.4616 mL	1.1541 mL
	50 mM	0.0369 mL	0.1847 mL	0.3693 mL	0.9233 mL
	60 mM	0.0308 mL	0.1539 mL	0.3078 mL	0.7694 mL
	80 mM	0.0231 mL	0.1154 mL	0.2308 mL	0.5770 mL
	100 mM	0.0185 mL	0.0923 mL	0.1847 mL	0.4616 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Cefminox sodium

1 Cited Publications

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Cefminox sodium

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Publications Citing Use of MedChemExpress (MCE) Cefminox sodium

All Antibiotic Isoforms

All PPAR Isoforms

All Prostaglandin Receptor Isoforms

All Akt Isoforms

All mTOR Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Cefminox sodium Related Classifications

HY-128932 Related Classifications