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  2. Bacterial
    Parasite
  3. Psicofuranine

Psicofuranine 

Cat. No.: HY-119819
Handling Instructions

Psicofuramine a nucleoside antibiotic and has the inhibition of xanthosine 5'-phosphate aminase. Psicofuranine also specifically inhibits GMP synthase, and interrupts parasite growth. Psicofuranine exhibits a dose-dependent inhibition of P. falciparum growth.

For research use only. We do not sell to patients.

Psicofuranine Chemical Structure

Psicofuranine Chemical Structure

CAS No. : 1874-54-0

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1 mg USD 385 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Psicofuramine a nucleoside antibiotic and has the inhibition of xanthosine 5'-phosphate aminase. Psicofuranine also specifically inhibits GMP synthase, and interrupts parasite growth. Psicofuranine exhibits a dose-dependent inhibition of P. falciparum growth[1][2].

IC50 & Target

Xanthosine 5'-phosphate aminase[2]
P. falciparum[1]
E. coli[1]

In Vitro

Psicofuranine specifically inhibits bacterial GMP synthase as demonstrated by isolation of Psicofuranine-resistant Escherichia coli mutants with mutations in the gene encoding GMP synthase and inhibition of bacterial growth. Psicofuranine exhibits a dose-dependent inhibition of P. falciparum growth with an IC50 of 0.3 mM. The Psicofuranine inhibitory concentration is similar to that of E. coli[1].

Molecular Weight

297.27

Formula

C₁₁H₁₅N₅O₅

CAS No.

1874-54-0

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (168.20 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3639 mL 16.8197 mL 33.6395 mL
5 mM 0.6728 mL 3.3639 mL 6.7279 mL
10 mM 0.3364 mL 1.6820 mL 3.3639 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

PsicofuranineBacterialParasiteGMPsynthaseE. coliP. falciparumxanthosine5'-phosphateaminasenucleosideantibioticInhibitorinhibitorinhibit

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Product name:
Psicofuranine
Cat. No.:
HY-119819
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