1. Anti-infection
  2. Bacterial
  3. Aristeromycin

Aristeromycin 

Cat. No.: HY-112639
Handling Instructions

Aristeromycin, an adenosine analog, is an antibiotic and a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor.

For research use only. We do not sell to patients.

Aristeromycin Chemical Structure

Aristeromycin Chemical Structure

CAS No. : 19186-33-5

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Description

Aristeromycin, an adenosine analog, is an antibiotic and a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor[1][2].

IC50 & Target

S-adenosylhomocysteine hydrolase[1]

In Vitro

The IC50 value of Aristeromycin against AHCY is 38.5 nM at 50 μM S-adenosylhomocysteine (SAH) (approximately equal to the Km: 48 μM), but 271 nM at 1000 µM SAH (20× Km). With 60 min of preincubation, the mean IC50 value of Aristeromycin at 50 μM SAH is 12.7 nM[1].
Aristeromycin has IC50 values of 3.2 μM for LNCaP-FGC cell growth and 0.88 μM for LNCaP-hr cell growth[1].
At least in part, Aristeromycin can regulate oncogenic EZH2 expression by inducing miR-26a[1].

Molecular Weight

265.27

Formula

C₁₁H₁₅N₅O₃

CAS No.

19186-33-5

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Aristeromycin
Cat. No.:
HY-112639
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