Polymyxin P1
Polymyxin P1 is a lipopeptide antibiotic belonging to the Polymyxin family, and it is a secondary metabolite produced by the rhizosphere bacterium Paenibacillus polymyxa M-1. Polymyxin P1 binds to bacterial outer membrane lipopolysaccharides, permeabilizes cell membranes, and induces dense protrusions on the cell surface of phytopathogenic Erwinia strains. Polymyxin P1 inhibits the growth of phytopathogenic Erwinia amylovora and E. carotovora. Polymyxin P1 can be used for the research of fire blight and soft rot.
For research use only. We do not sell to patients.
- CAS No.: 37331-24-1
- Formula: C54H94N16O14
- Molecular Weight:1191.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Polymyxin P1 strongly inhibits the growth of Erwinia amylovora Ea 273, Erwinia carotovora, Pseudomonas aeruginosa, Escherichia coli K12, and Micrococcus luteus, with inhibition zone diameters ranging from 18 mm to 23 mm, and also inhibits growth of several other bacterial strains to varying degrees[1].
Polymyxin P1 (20 μg/mL; 2 h) induces dense surface protrusions on Erwinia amylovora Ea 273 and Erwinia carotovora cells, indicating disruption of the bacterial cell outer membrane[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 37331-24-1
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Molecular Weight 1191.42
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Formula C54H94N16O14
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SMILES
O=C([C@@H](NC([C@H](CCNC([C@](NC([C@@H](NC([C@@H](NC([C@](NC1=O)([H])[C@H](O)C)=O)CCN)=O)CCN)=O)([H])[C@H](O)C)=O)NC([C@@H](CCN)NC([C@H]([C@H](O)C)NC([C@H](CCN)NC(CCCCC(C)CC)=O)=O)=O)=O)=O)CCN)N[C@@H]1CC2=CC=CC=C2
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Polymyxin P1 Related Classifications
HY-N15117 Related Classifications
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