Polymyxin P1 TFA 

Polymyxin P1 TFA is a lipopeptide antibiotic belonging to the Polymyxin family, and it is a secondary metabolite produced by the rhizosphere bacterium Paenibacillus polymyxa M-1. Polymyxin P1 TFA binds to bacterial outer membrane lipopolysaccharides, permeabilizes cell membranes, and induces dense protrusions on the cell surface of phytopathogenic Erwinia strains. Polymyxin P1 TFA inhibits the growth of phytopathogenic Erwinia amylovora and E. carotovora. Polymyxin P1 TFA can be used for the research of fire blight and soft rot^[1].

Polymyxin P1 TFA strongly inhibits the growth of Erwinia amylovora Ea 273, Erwinia carotovora, Pseudomonas aeruginosa, Escherichia coli K12, and Micrococcus luteus, with inhibition zone diameters ranging from 18 mm to 23 mm, and also inhibits growth of several other bacterial strains to varying degrees^[1].
Polymyxin P1 (20 μg/mL; 2 h) TFA induces dense surface protrusions on Erwinia amylovora Ea 273 and Erwinia carotovora cells, indicating disruption of the bacterial cell outer membrane^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1191.42 (free)

C₅₄H₉₄N₁₆O₁₄·xC₂HF₃O₂

OC(C(F)(F)F)=O.O=C([C@@H](NC([C@H](CCNC([C@](NC([C@@H](NC([C@@H](NC([C@](NC1=O)([H])[C@H](O)C)=O)CCN)=O)CCN)=O)([H])[C@H](O)C)=O)NC([C@@H](CCN)NC([C@H]([C@H](O)C)NC([C@H](CCN)NC(CCCCC(C)CC)=O)=O)=O)=O)=O)CCN)N[C@@H]1CC2=CC=CC=C2.[x]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Niu B, et al. Polymyxin P is the active principle in suppressing phytopathogenic Erwinia spp. by the biocontrol rhizobacterium Paenibacillus polymyxa M-1. BMC Microbiol. 2013 Jun 18;13:137.