Mycaminosyltylonolide
Based on 1 Customer Validation
Mycaminosyltylonolide is a potent antibiotic. Mycaminosyltylonolide shows antibacterial activity. Mycaminosyltylonolide inhibits luciferase synthesis.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 61257-02-1
- Formula: C31H51NO10
- Molecular Weight:597.74
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Mycaminosyltylonolid (3 µM) inhibits firefly luciferase mRNA translation in E. coli S30[1].
Mycaminosyltylonolid (0-128 µg/mL) shows antibacterial activity with MIC values of 1, 1, 2, 2, 1, 64 µg/mL for S. aureus FDA209Pa, S. aureus Smitha, S. aureus KUB857c, S. epidermidis KUB795g, E. faecalis ATCC29212h, K. pneumoniae NCTC9632h, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 61257-02-1
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Appearance Solid
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Molecular Weight 597.74
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Formula C31H51NO10
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Color White to off-white
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SMILES
O=CC[C@@H](C[C@H](C(/C=C/C(C)=C/[C@@H]([C@H](OC(C[C@H]([C@@H]1C)O)=O)CC)CO)=O)C)[C@@H]1O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C)O)N(C)C)O
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Structure Classification
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Initial Source
Streptomyces fradiae,
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (167.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Shishkina A, et al. Conjugates of amino acids and peptides with 5-o-mycaminosyltylonolide and their interaction with the ribosomal exit tunnel. Bioconjug Chem. 2013 Nov 20;24(11):1861-9. [Content Brief]
[2]. Sugawara A, et al. 5-O-Mycaminosyltylonolide antibacterial derivatives: design, synthesis and bioactivity. J Antibiot (Tokyo). 2017 Jul;70(8):878-887. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6730 mL | 8.3648 mL | 16.7297 mL | 41.8242 mL |
| 5 mM | 0.3346 mL | 1.6730 mL | 3.3459 mL | 8.3648 mL | |
| 10 mM | 0.1673 mL | 0.8365 mL | 1.6730 mL | 4.1824 mL | |
| 15 mM | 0.1115 mL | 0.5577 mL | 1.1153 mL | 2.7883 mL | |
| 20 mM | 0.0836 mL | 0.4182 mL | 0.8365 mL | 2.0912 mL | |
| 25 mM | 0.0669 mL | 0.3346 mL | 0.6692 mL | 1.6730 mL | |
| 30 mM | 0.0558 mL | 0.2788 mL | 0.5577 mL | 1.3941 mL | |
| 40 mM | 0.0418 mL | 0.2091 mL | 0.4182 mL | 1.0456 mL | |
| 50 mM | 0.0335 mL | 0.1673 mL | 0.3346 mL | 0.8365 mL | |
| 60 mM | 0.0279 mL | 0.1394 mL | 0.2788 mL | 0.6971 mL | |
| 80 mM | 0.0209 mL | 0.1046 mL | 0.2091 mL | 0.5228 mL | |
| 100 mM | 0.0167 mL | 0.0836 mL | 0.1673 mL | 0.4182 mL |
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