1. Anti-infection
    Immunology/Inflammation
    GPCR/G Protein
    Neuronal Signaling
  2. Antibiotic
    Bacterial
    Histamine Receptor
  3. Methdilazine

Methdilazine 

Cat. No.: HY-B1690
Handling Instructions

Methdilazine is an orally active antibiotic (histamine antagonist). Methdilazine can inhibit various mycobacterium with MIC values at 5-15 μg/mL in vitro and in vivo, which can be used for the research of infectious diseases.

For research use only. We do not sell to patients.

Methdilazine Chemical Structure

Methdilazine Chemical Structure

CAS No. : 1982-37-2

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Description

Methdilazine is an orally active antibiotic (histamine antagonist). Methdilazine can inhibit various mycobacterium with MIC values at 5-15 μg/mL in vitro and in vivo, which can be used for the research of infectious diseases[1][2].

IC50 & Target

MIC: 5-15 μg/mL (mycobacterium)

In Vitro

Methdilazine (0-20 μg/mL approximately, 18 h) inhibits kinds of mycobacterium with MIC values ranging from 5 μg/mL to 15 μg/mL[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: mycobacterium: M. smegmatis 798/1546, M.,fortuitum 1529, M. scrofulaceum 1323, M. gordonae 1324, M. rnarinum 50, M.,flavescens 1541, M. terrae 1450, M. tuberculosis, H37Ra 16, H37Rv 16, K1, K2, ICRC bacillus,'Skinsnes' bacillus.
Concentration: 0-20 μg/mL approximately
Incubation Time: 18 h
Result: Inhibited mycobacterium with MIC values ranging from 5 μg/mL to 15 μg/mL.
In Vivo

Methdilazine (Intraperitoneal injection, 10 μg/gm body wt/day, 6 weeks) is antagonistic to mycobacteria in H37Rv infected mice[1].
Methdilazine (Oral administration, 10 mg/kg per day, 28 days) improves survival of Mycobacterium Tuberculosis (Mtb) H37Rv infected mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: H37Rv infected mice[1]
Dosage: 10 μg/gm body wt/day, 6 weeks
Administration: Intraperitoneal injection
Result: Displayed an anti-mycobacterial activity to mycobacteria.
Animal Model: Mycobacterium Tuberculosis (Mtb) H37Rv infected Swiss albino male mice[2]
Dosage: 10 mg/kg per day for 28 days
Administration: Oral administration
Result: Increased surviving time to 28 days with no sign of disease, showed 71.42% survival.
Molecular Weight

296.43

Formula

C18H20N2S

CAS No.
SMILES

CN1CC(CN2C3=C(C=CC=C3)SC4=CC=CC=C24)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Methdilazine
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HY-B1690
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