1982-37-2
1982-37-2
Chemical Structure
Methdilazine
- CAS No.: 1982-37-2
- Formula:C18H20N2S
- Molecular Weight:296.43
IUPAC Name: 10-((1-methylpyrrolidin-3-yl)methyl)-10H-phenothiazine
InChIKey: HTMIBDQKFHUPSX-UHFFFAOYSA-N
SMILES: CN1CC(CN2C3=C(C=CC=C3)SC4=CC=CC=C24)CC1
Biological Activity: Methdilazine is an orally active antibiotic (histamine antagonist). Methdilazine can inhibit various mycobacterium with MIC values at 5-15 μg/mL in vitro and in vivo, which can be used for the research of infectious diseases[1][2].
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Methdilazine | Methdilazine is an orally active antibiotic (histamine antagonist). Methdilazine can inhibit various mycobacterium with MIC values at 5-15 μg/mL in vitro and in vivo, which can be used for the research of infectious diseases. | |||||||||||||||||||||
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References
- [1]. A N Chakrabarty, et al. Antimycobacterial activity of methdilazine (Md), an antimicrobic phenothiazine. APMIS. 1993 Jun;101(6):449-54. [Content Brief]
- [2]. Noton K Dutta, et al. Activity of the phenothiazine methdilazine alone or in combination with isoniazid or streptomycin against Mycobacterium tuberculosis in mice. J Med Microbiol. 2009 Dec;58(Pt 12):1667-1668. [Content Brief]
