TS 155-2
TS 155-2 (JBIR 100), an antimicrobial agent, is a Bafilomycin analogue and an antibiotic. TS 155-2 can be isolated from a culture of Streptomyces sp. TS 155-2 inhibits V-ATPase activity. V-ATPase is correlated with an increasing number of diseases such as osteopetrosis, male infertility and renal acidosis.
For research use only. We do not sell to patients.
- CAS No.: 1314486-37-7
- Formula: C39H60O11
- Molecular Weight:704.89
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
TS 155-2 shows cytotoxic effect against HeLa cells (IC50: 72.6 nM) at 48 h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1314486-37-7
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Molecular Weight 704.89
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Formula C39H60O11
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SMILES
O=C(O[C@@H]1C[C@@]([C@@H](C)[C@H](O)[C@@H]([C@H]([C@@H](OC)/C=C/C=C(C)/C[C@H](C)[C@H](O)[C@H](C)/C=C(C)/C=C2\C)OC2=O)C)(O)O[C@H](C(C)C)[C@H]1C)/C=C/C(O)=O
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Synonyms
JBIR 100
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Structure Classification
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Initial Source
Streptomyces sp. IR027-SDHV6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Ueda JY, et al. A new 16-membered tetraene macrolide JBIR-100 from a newly identified Streptomyces species. J Antibiot (Tokyo). 2010 Oct;63(10):627-9. [Content Brief]
[2]. Molloy EM, et al. Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products. Bioorg Med Chem. 2016 Dec 15;24(24):6276-6290. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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